Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2003-03-07
2010-11-09
Zara, Jane (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S006120, C435S091100, C435S091310, C435S455000, C435S458000, C536S023100, C536S024310
Reexamination Certificate
active
07829693
ABSTRACT:
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is substantially identical to at least a part of a target gene and which is no more than 49, preferably less than 25, nucleotides in length, and which comprises a complementary (antisense) RNA strand having a 1 to 4 nucleotide overhang at the 3′-end and a blunt 5′-end. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target gene, as well as for treating diseases caused by expression of the target gene, at low dosages (i.e., less than 5 milligrams, preferably less than 25 micrograms, per kg body weight per day). The invention also relates to methods for inhibiting the expression of a target gene, as well as methods for treating diseases caused by the expression of the gene.
REFERENCES:
patent: 4309492 (1982-01-01), Bernard
patent: 5112734 (1992-05-01), Kramer et al.
patent: 5225347 (1993-07-01), Goldberg et al.
patent: 5246921 (1993-09-01), Reddy et al.
patent: 5340318 (1994-08-01), Kunihiro
patent: 5472802 (1995-12-01), Holland et al.
patent: 5496698 (1996-03-01), Draper et al.
patent: 5525468 (1996-06-01), McSwiggen
patent: 5574142 (1996-11-01), Meyer, Jr. et al.
patent: 5616459 (1997-04-01), Kramer et al.
patent: 5635385 (1997-06-01), Leopold et al.
patent: 5639655 (1997-06-01), Thompson et al.
patent: 5712257 (1998-01-01), Carter
patent: 5811275 (1998-09-01), Wong-Staal et al.
patent: 5811300 (1998-09-01), Sullivan et al.
patent: 5814500 (1998-09-01), Dietz
patent: 5824519 (1998-10-01), Norris et al.
patent: 5837510 (1998-11-01), Goldsmith et al.
patent: 5854067 (1998-12-01), Newgard et al.
patent: 5864028 (1999-01-01), Sioud
patent: 5866701 (1999-02-01), Hampel et al.
patent: 5891717 (1999-04-01), Newgard et al.
patent: 5898031 (1999-04-01), Crooke
patent: 5908779 (1999-06-01), Carmichael et al.
patent: 5939262 (1999-08-01), Pasloske et al.
patent: 5968737 (1999-10-01), Ali-Osman et al.
patent: 5985620 (1999-11-01), Sioud
patent: 6057156 (2000-05-01), Akhtar et al.
patent: 6071890 (2000-06-01), Scheule et al.
patent: 6077705 (2000-06-01), Duan et al.
patent: 6080851 (2000-06-01), Pachuk et al.
patent: 6087164 (2000-07-01), Hochberg et al.
patent: 6087172 (2000-07-01), Veerapaneni et al.
patent: 6099823 (2000-08-01), Falb
patent: 6100087 (2000-08-01), Rossi et al.
patent: 6100444 (2000-08-01), Frelinger et al.
patent: 6107094 (2000-08-01), Crooke
patent: 6183959 (2001-02-01), Thompson
patent: 6187585 (2001-02-01), Bennett et al.
patent: 6224868 (2001-05-01), Wong et al.
patent: 6225291 (2001-05-01), Lewin et al.
patent: 6245560 (2001-06-01), Lisziewicz
patent: 6245748 (2001-06-01), Wellstein et al.
patent: 6255071 (2001-07-01), Beach et al.
patent: 6346398 (2002-02-01), Pavco et al.
patent: 6355415 (2002-03-01), Wagner et al.
patent: 6410176 (2002-06-01), Genc et al.
patent: 6423489 (2002-07-01), Anderson et al.
patent: 6482803 (2002-11-01), Roth et al.
patent: 6486299 (2002-11-01), Shimkets
patent: 6506559 (2003-01-01), Driver et al.
patent: 6573046 (2003-06-01), Kmiec et al.
patent: 2002/0086356 (2002-07-01), Tuschl et al.
patent: 2002/0114784 (2002-08-01), Li et al.
patent: 2002/0123034 (2002-09-01), Canaani et al.
patent: 2002/0132346 (2002-09-01), Cibelli
patent: 2002/0162126 (2002-10-01), Beach et al.
patent: 2002/0173478 (2002-11-01), Gewirtz
patent: 2003/0027783 (2003-02-01), Zernicka-Goetz et al.
patent: 2003/0108923 (2003-06-01), Tuschl et al.
patent: 2003/0125281 (2003-07-01), Lewis et al.
patent: 2003/0143732 (2003-07-01), Fosnaugh et al.
patent: 2003/0148341 (2003-08-01), Sin et al.
patent: 2003/0157030 (2003-08-01), Davis et al.
patent: 2003/0176671 (2003-09-01), Reed et al.
patent: 2003/0180756 (2003-09-01), Shi et al.
patent: 2003/0190635 (2003-10-01), McSwiggen
patent: 2003/0198627 (2003-10-01), Arts et al.
patent: 2334951 (1999-12-01), None
patent: 196 18 797 (1997-11-01), None
patent: 196 31 919 (1998-07-01), None
patent: 199 56 568 (1999-11-01), None
patent: 200 23 125 (2000-01-01), None
patent: EP 1 214 945 (2000-01-01), None
patent: 19956568 (2000-08-01), None
patent: 101 00 588 (2001-01-01), None
patent: 10100586 (2001-01-01), None
patent: 10155280 (2001-10-01), None
patent: 10158411 (2001-11-01), None
patent: 101 63 098 (2001-12-01), None
patent: 101 00 586 (2002-04-01), None
patent: 102 30 966 (2002-07-01), None
patent: 102 30 997 (2002-07-01), None
patent: 101 00 587 (2002-11-01), None
patent: 10163098 (2003-04-01), None
patent: 1 001 666 (2000-05-01), None
patent: 00126325.0 (2001-01-01), None
patent: 1 107 340 (2001-06-01), None
patent: WO 92/19732 (1992-11-01), None
patent: WO 94/01550 (1994-01-01), None
patent: WO 98/05770 (1998-02-01), None
patent: WO 98/53083 (1998-11-01), None
patent: WO 99/15682 (1999-04-01), None
patent: WO 99/32619 (1999-07-01), None
patent: WO 99/49029 (1999-09-01), None
patent: WO 99/53050 (1999-10-01), None
patent: WO 99/61631 (1999-12-01), None
patent: WO 00/01846 (2000-01-01), None
patent: WO 00/44895 (2000-08-01), None
patent: WO 00/44914 (2000-08-01), None
patent: WO 00/63364 (2000-10-01), None
patent: WO 00/68374 (2000-11-01), None
patent: WO 01/18197 (2001-03-01), None
patent: WO 01/29058 (2001-04-01), None
patent: WO 01/36646 (2001-05-01), None
patent: WO 01/42443 (2001-06-01), None
patent: WO 01/48183 (2001-07-01), None
patent: WO 01/68836 (2001-09-01), None
patent: WO 01/70949 (2001-09-01), None
patent: WO 01/75164 (2001-10-01), None
patent: WO 01/92513 (2001-12-01), None
patent: WO 02/16620 (2002-02-01), None
patent: WO 02/26780 (2002-04-01), None
patent: WO 02/44321 (2002-06-01), None
patent: WO 02/44321 (2002-06-01), None
patent: WO 02/055692 (2002-07-01), None
patent: WO 02/055693 (2002-07-01), None
patent: WO 02/061034 (2002-08-01), None
patent: WO 02/068635 (2002-09-01), None
patent: WO 02/068637 (2002-09-01), None
patent: WO 03/006477 (2003-01-01), None
patent: WO 03/012052 (2003-02-01), None
patent: WO 03/012082 (2003-02-01), None
patent: WO 03/016572 (2003-02-01), None
patent: WO 03/033700 (2003-04-01), None
patent: WO 03/035082 (2003-05-01), None
patent: WO 03/035083 (2003-05-01), None
patent: WO 03/035868 (2003-05-01), None
patent: WO 03/035869 (2003-05-01), None
patent: WO 03/035870 (2003-05-01), None
patent: WO 03/035876 (2003-05-01), None
patent: WO 03/070283 (2003-08-01), None
patent: WO 03/070750 (2003-08-01), None
patent: WO 03/070969 (2003-08-01), None
patent: WO 03/070972 (2003-08-01), None
patent: WO 03/074654 (2003-09-01), None
patent: WO 03/080794 (2003-10-01), None
patent: WO 03/080807 (2003-10-01), None
Agrawal, S. et al., Molecular Med. Today, vol. 6, pp. 72-81 (2002).
Branch, A.D., Trends in Biochem. Sci., vol. 23, pp. 45-50 (1998).
Crooke, S.T., Antisense Research & Application, Chapter 1, pp. 1-50, Ed. by S. Crooke, Publ. by Springer-Verlag (1998).
Peracchi, A., Rev. Med. Virol., vol. 14, pp. 47-64 (2003).
Chirila, T.V. et al., Biomaterials, vol. 23, pp. 321-342 (2002).
Opalinska, J.B. et al., Nature Reviews, vol. 1, pp. 503-514 (2002).
Zamore et al., Cell, vol. 101, pp. 25-33 (2000).
Elbashir et al (Nature, vol. 411, pp. 494-498 (2001).
Z-Axis Connector Company, Silver STAX, www.z-axiscc.com/prodstax.htm, Accessed Jul. 19, 2001.
Z-Axis Connector Company, LCD Connectors, www.z-axiscc.com/prodlcd.htm, Accessed Jul. 19, 2001.
Holen, T. et al., (2002), “Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor”,Nucleic Acids Research, 30(8):1757-1766.
Ambros, V., (2001), “Dicing Up RNAs”,Science, 293:811-813.
Elbashir, S.M. et al., (2001), “Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells”,Nature, 411:494-498.
Gautschi, O. et al., (2001), “Activity of a Novel bcl-2/bcl-xL-Bispecific Antisense Oligonucleotide Against Tumors of Diverse Histologic Origins”,Journal of the National Cancer Institute, 93(6):463-471.
Lipardi, C. et al., (2001), “RNAi as Random Degradative PCR:
Hadwiger Philipp
Kreutzer Roland
Limmer Stefan
Limmer Sylvia
Alnylam Pharmaceuticals, Inc.
Fenwick & West LLP
Zara Jane
LandOfFree
Compositions and methods for inhibiting expression of a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for inhibiting expression of a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inhibiting expression of a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4171702