Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-08-09
2011-08-09
Chong, Kimberly (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024310, C536S024100, C435S006120, C435S325000, C435S375000, C514S04400A
Reexamination Certificate
active
07994309
ABSTRACT:
The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a complementary RNA strand having a complementary region that is substantially complementary to a portion of the mutant gene, and which is partially complementary to the corresponding wild-type gene. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.
REFERENCES:
patent: WO 2003/040366 (2003-05-01), None
Summons for oral hearing according to regulation 115(1) EPA for European Patent Application No. 02779511, Oct. 15, 2010, 12 pages.
Memorandum from European Patent Office regarding scheduled date for oral hearing on Mar. 10, 2011 will remain in effect, European Patent Application No. EP 02779511.1, Patent No. EP 1438405, Feb. 22, 2011, 2 pages.
Decision of Refusal of European Patent Application No. EP 02779511.1, from the European Patent Office on Apr. 26, 2011, 45 pages.
Minutes of Oral Proceedings, which took place on May 10, 2011, for European Patent Application No. EP 02779511.1, from the European Patent Office on Apr. 20, 2011, 9 pages.
John Matthias
Kreutzer Roland
Limmer Stefan
Alnylam Pharmaceuticals, Inc.
Chong Kimberly
Fenwick & West LLP
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