Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-08-09
2010-10-19
Falk, Anne-Marie (Department: 1632)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S391300
Reexamination Certificate
active
07816497
ABSTRACT:
Activated C3 (C3a) and its receptor (C3aR) and activated C5 (C5a) and its receptor (C5aR) have been shown to induce vascular endothelial growth factor (VEGF) expression in vitro and in vivo. Compositions and methods for inhibiting C3a, C3aR, C5a and C5aR for the treatment and/or prevention of neovascular disease are provided. Also provided are Novel therapeutic targets and diagnostic markers for choroidal neovascularization.
REFERENCES:
Werfel et al. (2000) Activated human T lymphocytes express a functional C3a receptor. J. of Immunol. 165: 6599-6605.
Zwirner et al. (1999) Evaluation of C3a receptor expression on human leucocytes by the use of novel monoclonal antibodies. Immunology 97: 166-172.
Ambati, et al. “An animal model of age-related macular degeneration in senescent macrophage recruitment impaired mice,” Abstracts of the Annual Meeting of the Association for Research in Vision and Ophthamology, May 4, 2003, Database Dialog, Biosis No. 2003005125464, Abstract No. 1718.
Grossniklaus et al., “Marcrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization,” Molecular Vision, Apr. 21, 2002, pp. 119-126, vol. 8, No. 15.
Lu, Bao., et al, “Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1-deficient Mice.” J. Exp. Med, Feb. 16, 1998, vol. 187(4), pp. 601-608, ISSN 0022-1007.
Kuziel, William, A.., et al. “Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC Chemokine receptor 2.” Proceeding of the National Academy of the Sciences, USA, vol. 94, No. 22, Oct. 1997, pp. 12053-12058.
Raisler, Brian J., et al. “Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization.” PNAS, Jun. 25, 2002, vol. 99, No. 13, pp. 8909-8914.
Acland, Gregory, M., et al. “Gene therapy restores vision in canine model of childhood blindness.” Nature Genetics, vol. 28, May 2001, pp. 92-95.
Elner, Victor, M., et al. “Cell-Associated Human Retinal Pigment Epithelium Interleukin-8 and Monocyte Chemotactic Protein-1: Immunochemical and In-situ Hybridization Analyses.” Experimental Eye Research, Dec. 1997, vol. 65, No. 6, pp. 781-789.
Doetschman, T. (1999) Interpretation of phenotype in genetically engineered mice. Laboratory Animal Science 49(2): 137-143.
Donehower et al. (1995) Effects of genetic background on tumorigenesis in p53-deficient mice. Molecular Carnicogenesis 14: 16-22.
Jacks et al. (1992) Effects of an Rb mutation in the mouse. Nature 359: 295-300.
Jaenisch et al. (1988) Transgenic Animals. Science 240: 1468-1474.
Kuehn et al. (1987) A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326: 295-298.
Moens et al. (1993) Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-Myc locus. Development 119: 485-499.
Petridou et al. (2003) Heterogeneous inducible mammary-specific expression of JAB/SOCS1 in lactating transgenic mice is associated with no obvious phenotype, even at the cellular level. Transgenic Research 12: 693-706.
Sigmund, CD (2000) Viewpoint: Are studies in genetically altered mice out of control? Arterioscler. Thromb. Vasc. Biol. 20: 1425-1429.
United States Office Action issued in U.S. Appl. No. 10/685,705, dated Oct. 12, 2006.
Falk Anne-Marie
McDermott Will & Emery LLP
University of Kentucky
LandOfFree
Compositions and methods for inhibiting drusen complement... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for inhibiting drusen complement..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inhibiting drusen complement... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4153870