Compositions and methods for inhibiting cytochrome P450

Details Compositions and methods for inhibiting cytochrome P450 Compositions and methods for inhibiting cytochrome P450

2007-08-20

2011-11-01

Fetterolf, Brandon (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08048871

ABSTRACT:
Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

REFERENCES:
patent: WO 2005/087728 (2005-09-01), None
Dorwald, F. ‘Side Reactions in Organic Synthesis, A Guide to Successful Synthesis Design’ Wiley-VCH, Preface, p. ix, 2005.
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Horig et al ‘From bench to clinic and back: perspective on the 1stIQPC translation research conference’ Journal of Translational Medicine, 2(44), p. 1-8, 2004.
Schafer et al ‘Failure is an option: learning from unsuccessful proof-of-concept trials’ Drug Discovery Today, 13(21/22), p. 913-916, 2008.

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