Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-12-11
2010-11-16
Monshipouri, Maryam (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07833980
ABSTRACT:
The finding that Dickkopf1 (Dkk1) is a dual function protein demonstrates a mechanism for the coordination of cell migration and antagonism of Wnt/β-catenin signaling during developmental and pathological processes. The profile of Dkk proteins expressed by human breast cancers correlates with indicators of outcome: Dkk1 associates with markers of poor prognosis whereas expression of single function Dkk2 or Dkk3 (which inhibit Wnt/β-catenin signaling and promote migration, respectively) correlates with phenotypes reflective of good prognosis. Therefore, the pro-migratory activities of Dkk1 and 3 identified here offer new insights into breast cancer progression and a potential avenue for therapeutic intervention.
REFERENCES:
patent: WO 98/46755 (1998-10-01), None
Brott and Sokol, “Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins”,Molecular and Cellular Biology, 22(17):6100-6110 (2002).
Glinka et al., “Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction”,Nature, 391(6665):357-62 (1998).
Krupnik et al., “Functional and structural diversity of the human Dickkopf gene family”,Gene, 238(2):301-13 (1999).
Lee et al., “Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma”,Biochem. Biophys Res. Commun., 323(4):1246-50 (2004).
Li et al., “Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled”,J. Biological Chemistry, 277(8):5977-5981 (2002).
Mao and Niehrs, “Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling”,Gene. 302(1-2):179-83 (2003).
Monaghan et al., “Dickkopf genes are co-ordinately expressed in mesodermal lineages”,Mech Dev., 87(1-2):45-56 (1999).
Gupta Ruchika
Mercola Mark
DLA Piper (LLP) US
Monshipouri Maryam
The Burnham Institute
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