Compositions and methods for inhibiting car gene expression...

Details Compositions and methods for inhibiting car gene expression... Compositions and methods for inhibiting car gene expression...

2008-07-31

2010-10-19

Angell, J. E (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120

Reexamination Certificate

active

07816338

ABSTRACT:
The present invention provides short interfering ribonucleic acid (siRNA), compositions and methods for inhibiting the CAR gene expression simply and rapidly, which can be used for evaluating toxicity of a chemical substance.

REFERENCES:
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2006/0288436 (2006-12-01), Moore et al.
patent: 0225270 (2002-03-01), None
patent: 2006064197 (2006-06-01), None
European Search Report for the related European Application No. 08252595.7 dated Dec. 1, 2008.
Chen et al.; “Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)”; Toxicology, vol. 231, No. 2-3; Feb. 24, 2007; available online Dec. 22, 2006; pp. 224-233.
Yamamoto, Yukio et al.; “The orphan nuclear receptor contitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice”; Cancer Resaerch, vol. 64, No. 20; Oct. 15, 2004; pp. 7197-7200.
Yang et al.; “A novel PNAi library based on partially randomized consensus sequences of nuclear receptors” Identifying the receptors involved in amyloid beta degradation; Genomics; vol. 88, No. 3; Aug. 23, 2006; available online May 2, 2006; pp. 282-292.
Swales, Karen et al.; “CAR, driving into the future”; Molecular Endocrinology; vol. 18, No. 7; Jul. 2004; pp. 1589-1598.
Yamada, Hideyuki et al.; “Induction of the hepatic cytochrome P4502B subfamily by xenobiotics: Research history, evolutionary aspect, relation to tumorigenesis, and mechanism”; Current Drug Metabolism; vol. 7, No. 4; May 2006; pp. 397-409.

Affiliated with

Also associated with

Rating

Compositions and methods for inhibiting car gene expression... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for inhibiting car gene expression..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inhibiting car gene expression... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4233659