Compositions and methods for inhibiting 5-α reductase

Details Compositions and methods for inhibiting 5-α reductase Compositions and methods for inhibiting 5-α reductase

2007-11-16

2010-06-29

Hoffman, Susan C (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

Containing or obtained from palmaceae

C424S777000

Reexamination Certificate

active

07744935

ABSTRACT:
Disclosed herein are compositions for controlling androgen activity in target organs and cells through the modulation of a 5-α-reductase activity. In certain aspects, these compositions are employed to modulate androgenic activity by inhibiting the formation and availability of active androgen in target cells. As a result, the present invention is directed toward the treatment of a wide variety of conditions including, but not limited to, the treatment of prostatic hyperplasia, prostatic cancer, hirsutism, acne, male pattern baldness, seborrhea, and other diseases related to androgen hyperactivity. Several of these compositions have been shown to effectively decrease body weight, and in some cases, to decrease the weight of an androgen-dependent body organ, such as the prostate and other organs.

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Hirata (Biol. Pharm. Bull. (2007), vol. 30, No. 12, pp. 2402-2405).
Iehlé, et al., Human Prostatic Steroid 5a-Reductase Isoforms-A Comparative Study of Selective Inhibitors. Steroid Biochem. Molec. Biol. vol. 54, No. 5/6, pp. 273-279, 1995.

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