Compositions and methods for inducing osteogenesis

Details Compositions and methods for inducing osteogenesis Compositions and methods for inducing osteogenesis

2007-09-25

2007-09-25

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S263370, C514S263380, C514S263400, C544S118000, C544S276000, C544S277000

Reexamination Certificate

active

10687220

ABSTRACT:
The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage, using compounds of the following formula:wherein R4is a functional group including, for example, C1-4alkyl, C3-8cycloalkyl, hydroxyl-C1-4alkyl, aryl-C0-3alkyl, substituted with 0-2 R4agroups, and heterocyclo-C0-2alkyl, optionally substituted with C1-4alkyl; R5is hydrogen and R6is a functional group including, for example, halogen, C1-4alkyl, —C(O)—C1-4alkyl, —SO2—N(R2bR2b), halo—C1-4alkyl, —O-aryl and —N(R7R8), or when R5and R6are on adjacent ring atoms they are optionally taken together to form —O—(CH2)1-2—O—; and all pharmaceutically acceptable salts and hydrates thereof.

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