Compositions and methods for inducing apoptosis

Details Compositions and methods for inducing apoptosis Compositions and methods for inducing apoptosis

1997-06-18

1999-08-10

Degen, Nancy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 4351723, 4353201, 536 231, 536 241, 536 245, C07H 2104, A61K 4800

Patent

active

059359374

ABSTRACT:
Compositions and methods for the treatment of malignant cells are disclosed, particularly antisense nucleic acid molecules and their use in inhibiting the deregulated cellular proliferation of tumor cells, while not adversely affecting the growth of normal cells.

REFERENCES:
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M. Crescenzi et al., Proc. Natl. Acad. Sci. USA, 85: 4869-4873 (1988).
H. Dorai et al., Nucleic Acids Research, 17(15): 6412 (1989).
M. Seto et al., The EMBO Journal, 7(1): 123-131 (1988).
M. Cleary et al., Cell, 47: 19-28 (1986).
F. Keith et al., Leukemia, 9: 131-138 (1995).
S. Kitada et al., Antisense Research and Development, 4: 71-79 (1994).
Stull et al "Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects" Pharmaceutical Research vol. 12(4)485-483 1995.

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