Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-08-14
2007-08-14
Li, Q. Janice (Department: 1633)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S450000, C435S455000
Reexamination Certificate
active
09845938
ABSTRACT:
Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particular, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.
REFERENCES:
patent: 4027013 (1977-05-01), Bick et al.
patent: 4188373 (1980-02-01), Krezanoski
patent: 4609546 (1986-09-01), Hiratani
patent: 4740498 (1988-04-01), Hirao et al.
patent: 4772466 (1988-09-01), Allison et al.
patent: 5412072 (1995-05-01), Sakurai et al.
patent: 5417982 (1995-05-01), Modi
patent: 5436170 (1995-07-01), Cornell et al.
patent: 5449513 (1995-09-01), Yokoyama et al.
patent: 5554372 (1996-09-01), Hunter
patent: 5648071 (1997-07-01), Hunter et al.
patent: 5656611 (1997-08-01), Kabanov et al.
patent: 5696090 (1997-12-01), McGregor et al.
patent: 5830877 (1998-11-01), Carson et al.
patent: 5840319 (1998-11-01), Alakhov et al.
patent: 5885590 (1999-03-01), Hunter et al.
patent: 6218438 (2001-04-01), Alakhov et al.
patent: 6277410 (2001-08-01), Kabanov et al.
patent: 6359054 (2002-03-01), Lemieux et al.
patent: 6387406 (2002-05-01), Kabanov et al.
patent: 6589940 (2003-07-01), Raz et al.
patent: 6656459 (2003-12-01), Kabanov et al.
patent: 6677313 (2004-01-01), Mathiowitz et al.
patent: 2002/0019358 (2002-02-01), Manthorpe et al.
patent: 0 211 601 (1986-07-01), None
patent: WO92/00101 (1992-01-01), None
patent: WO 96/15778 (1996-05-01), None
patent: WO 96/16541 (1996-06-01), None
patent: WO 96/40055 (1996-12-01), None
patent: WO 96/40056 (1996-12-01), None
patent: WO 99/39731 (1999-08-01), None
Jakob et al, J Immunol 1998;1998;161:3042-9.
Denis-Mize et al, Gene Ther. Dec. 2000;7:2105-12.
Alexander V. Klabanov et al., A New Class of Drug Carriers: Micelles of Poly (oxyethylene)-poly (oxypropylene) Block Copolymers as Microcontainers for Drug Targeting From Blood in Brain, Journal of Controlled Release 22:141-158 (1992).
Alexander V. Klabanov et al., Interpolyelectrolyte and Block Ionomer Complexes for Gene Delivery: Physico-chemical Aspects, Advanced Drug Delivery Reviews, 30:49-60 (1998).
Elena V. Batrakova et al., Effects of Pluronic Block Copolymers on Drug Absorption in Caco-2 Cell Monolayers, Pharmaceutical Research, vol. 15, No. 6, pp. 850 (1998).
Vladimir P. Chekhonin et al., Fatty Acid Acylated Fab-fragments of Antibodies to Neurospecific Proteins as Carriers for Neuroleptic Targeted Delivery in Brain, FEBS 287, pp. 149-152 (1991).
Devery A. Howerton et al. Inductin of Macrophage la Expression in Vivo by a Synthetic Block Copolymer, L81, Journal of Immunology, vol. 144, pp. 1578-1584 (1990).
Otmane Boussif et al. , A Versatile Vector for Gene and Oligonucleotide Transfer Into Cells In Culture and In Vivo: Polyethylenimine, Proc. Natl. Acad. Sci. USA, vol. 92, pp. 7297-7301 (1995).
James G. McArthur et al., Induction of Protective Anti-Tumor Immunity by Gene-Modified Dendritic Cells, Journal of Immunotherapy, 21(1): 41-47 (1998).
H-K Nguyen et al., Evaluation of Polyether-Polyethyleneimine Graft Copolymers as Gene Transfer Agents, Gene Therapy (2000) 7, pp. 126-138 (2000).
Alakhov Valery
Guerin Nadia
Kabanov Alexander V.
Lemieux Pierre
Li Q. Janice
Mathews, Shepherd, McKay & Bruneau, P.A.
Supratek Pharma Inc.
LandOfFree
Compositions and methods for inducing activation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for inducing activation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inducing activation of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3829972