Compositions and methods for increasing bone mineralization

Details Compositions and methods for increasing bone mineralization Compositions and methods for increasing bone mineralization

2002-03-07

2009-08-11

Kam, Chih-Min (Department: 1656)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023200, C435S320100, C435S252300, C435S254110, C435S325000, C435S419000, C435S069100

Reexamination Certificate

active

07572899

ABSTRACT:
Nucleic acids relating to human TGF-β binding proteins are disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4376110 (1983-03-01), David et al.
patent: 4411993 (1983-10-01), Gillis
patent: 4427115 (1984-01-01), Laipply
patent: 4543439 (1985-09-01), Frackelton, Jr. et al.
patent: RE32011 (1985-10-01), Zimmerman et al.
patent: 4837440 (1989-06-01), Burtscher et al.
patent: 4902614 (1990-02-01), Wakabayashi et al.
patent: 5070108 (1991-12-01), Margolis
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5399363 (1995-03-01), Liversidge et al.
patent: 5453492 (1995-09-01), Bützow et al.
patent: 5466468 (1995-11-01), Schneider et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5552157 (1996-09-01), Yagi et al.
patent: 5565213 (1996-10-01), Nakamori et al.
patent: 5567434 (1996-10-01), Szoka, Jr.
patent: 5627052 (1997-05-01), Schrader et al.
patent: 5641515 (1997-06-01), Ramtoola et al.
patent: 5698426 (1997-12-01), Huse
patent: 5738868 (1998-04-01), Shinkarenko et al.
patent: 5780263 (1998-07-01), Hastings et al.
patent: 5795587 (1998-08-01), Gao et al.
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5837458 (1998-11-01), Minshull et al.
patent: 5877397 (1999-03-01), Lonberg et al.
patent: 6054561 (2000-04-01), Ring
patent: 6057421 (2000-05-01), Muller et al.
patent: 6117911 (2000-09-01), Grainger et al.
patent: 6133426 (2000-10-01), Gonzalez et al.
patent: 6180370 (2001-01-01), Queen et al.
patent: 6207153 (2001-03-01), Dan et al.
patent: 6395511 (2002-05-01), Brunkow et al.
patent: 6489445 (2002-12-01), Brunkow et al.
patent: 6495736 (2002-12-01), Brunkow et al.
patent: 6703199 (2004-03-01), Koide
patent: 6803453 (2004-10-01), Brunkow et al.
patent: 6806055 (2004-10-01), Berman et al.
patent: 6815201 (2004-11-01), Pinter
patent: 2003/0165410 (2003-09-01), Taylor
patent: 2003/0186915 (2003-10-01), Pan et al.
patent: 2004/0009535 (2004-01-01), Brunkow et al.
patent: 2004/0058321 (2004-03-01), Brunkow et al.
patent: 2004/0141875 (2004-07-01), Doshi
patent: 2004/0146888 (2004-07-01), Paszty et al.
patent: 2004/0158045 (2004-08-01), Brunkow et al.
patent: 2005/0106683 (2005-05-01), Winkler et al.
patent: 2005/0238646 (2005-10-01), Ledbetter et al.
patent: 2006/0233801 (2006-10-01), Brunkow et al.
patent: 2007/0110747 (2007-05-01), Paszty et al.
patent: 102 55 152 (2004-06-01), None
patent: 2 838 379 (2003-10-01), None
patent: 4-141095 (1992-05-01), None
patent: WO 91/13152 (1991-09-01), None
patent: WO-92/02551 (1992-02-01), None
patent: WO-92/06693 (1992-04-01), None
patent: WO 92/06693 (1992-04-01), None
patent: WO-95/30003 (1995-11-01), None
patent: WO-98/21335 (1998-05-01), None
patent: WO-99/03996 (1999-01-01), None
patent: WO 99/06554 (1999-02-01), None
patent: WO-99/15556 (1999-04-01), None
patent: WO-00/32773 (2000-06-01), None
patent: WO-00/75317 (2000-12-01), None
patent: WO-01/64885 (2001-09-01), None
patent: WO-01/92308 (2001-12-01), None
patent: WO-01/98491 (2001-12-01), None
patent: WO-02/24888 (2002-03-01), None
patent: WO-03/106657 (2003-12-01), None
patent: WO-2005/003158 (2005-01-01), None
patent: WO-2005/014650 (2005-02-01), None
Brunkow et al. Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot-Containing Protein. Am. J. Hum. Genetics (Feb. 9, 2001) 68: 577-589.
Birren et al., EMBL Sequence Database, Accession No. AC003098, Nov. 14, 1997.
Bonaldo et al., “Normalization and Subtraction: Two Approaches to Facilitate Gene Discovery,”Genome Res. 6(9):791-806, 1996.
Bonaldo et al., EMBL Sequence Database, Accession No. AI113131, Sep. 4, 1998.
Fujiwara et al., Genbank Accession No. D79813, Feb. 9, 1996.
Hillier et al., EMBL Sequence Database, Accession No. AA393939, May 19, 1997.
Hillier et al., Genbank Accession No. AA393768, Apr. 24, 1997.
Hsu et al., “TheXenopusDorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities,”Molecular Cell1: 673-683, Apr. 1998.
Iemura et al., “Direct Binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in earlyXenopusembryo,”Proc. Natl. Acad. Sci. USA 95: 9337-9342, Aug. 1998.
Khosla and Riggs, “Concise Review for Primary-Care Physicians. Treatment Options for Osteoporosis,”Mayo Clin Proc70: 978-982, 1995.
Riggs, “Overview of Osteoporosis,”West J. Med. 154: 63-77, Jan. 1991.
Cook et al., J. Biol. Chem., 280(48):40177-186 (2005).
Keller et al., Nat. Struct. Mol. Biol., 11(5): 481-488 (2004).
Alting-Mees et al., “Monoclonal Antibody Expression Libraries: A Rapid Alternative to Hybridomas,”Strategies in Molecular Biology, 3:1-9 (1990).
Alves et al., “Sclerosteosis: A Marker of Dutch Ancestry?”Rev. Bras. Genet., 4:825-834 (1982).
Angal et al., “A Single Amino Acid Substitution Abolishes the Heterogeneity of Chimeric Mouse/Human (IgG4) Antibody,”Mol. Immunol., 30(1):105-108 (1993).
Avsian-Kretcher et al., “Comparative Genomic Analysis of the Eight-Membered Ring Cystine Knot-Containing Bone Morphogenetic Protein Antagonists,”Mol. Endo., 18(10:1-12 (2004).
Babcook et al., “A Novel Strategy for Generating Monoclonal Antibodies from Single, Isolated Lymphocytes Producing Antibodies of Defined Specificities,”Proc. Natl. Acad. Sci.(USA), 93:7843-7848 (1996).
Baines et al., “Purification of Immunoglobulin G (IgG),” Methods in Molecular Biology, 10:79-104, The Humana Press, Inc. (1992).
Balemans et al., “Increased Bone Density in Sclerosteosis is due to the Deficiency of a Novel Secreted Protein (SOST),”Hum. Mol. Genet., 10:537-543 (2001).
Beighton et al., “The Clinical Features of Sclerosteosis,”Annals of Internal Medicine, 84:393-397 (1976).
Beighton et al., “The Syndromic Status of Sclerosteosis and van Buchem Disease,”Clinical Genetics, 25:175-181 (1984).
Bird et al., “Single-Chain Antigen-Binding Proteins,”Science, 242:423-426 (1988).
Black et al., “A Somatic Cell Hybrid Map of the Long Arm of Human Chromosome 17, Containing the Familial Breast Cancer Locus (BRCAI),”Am. J. Hum. Genet., 52:702-710 (1993).
Boden et al., “Glucocorticoid-Induced Differentiation of Fetal Rat Calvarial Osteoblasts is Mediated by Bone Morphogenetic Protein-6,”Endocrinology, 138(7):2820-2828 (1997).
Boerner et al., “Production of Antigen-Specific Human Monoclonal Antibodies from in Vitro-Primed Human Splenocytes,”J. Immunol., 147:86-95 (1991).
Bostrom et al., “Immunolocalization and Expression of Bone Morphogenetic Proteins 2 and 4 in Fracture Healing,”J. Orth. Res., 13:357-367 (1995).
Bowie et al., “A Method to Identify Protein Sequences that Fold into a Known Three-Dimensional Structure,”Science, 253:164-170 (1991).
Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,”Science247:1306-1310 (1990).
Brown, T., “Hybridization Analysis of DNA Blots,” 2.10.1-2.10.16 (2000).
Bruggemann et al., “Production of Human Antibody Repertoires in Transgenic Mice,”Curr. Opin. Biotechnol., 8:455-458 (1997).
Burton et al., “Human Antibodies from Combinatorial Libraries,”Adv. Immunol., 57:191-280 (1994).
Byrne et al., “CD4+CD45RBHi T Cell Transfer Induced Colitis in Mice is Accompanied by Osteopenia which is Treatable with Recombinant Human Osteoprotegerin,”Gut, 54:78-86 (2005).
Chandran et al.,“Recent Trends in Drug Delivery Systems: Liposomal Drug Delivery System—Preparation and Characterisation,”Indian J. Exp. Biol., 35(8):801-809 (1997).
Chou et al., “Empirical Prediction of Protein Conformation,”Ann. Rev. Biochem., 47:251-276 (1979).
Clark, &#x

Affiliated with

Also associated with

Rating

Compositions and methods for increasing bone mineralization does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for increasing bone mineralization, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for increasing bone mineralization will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4101245