Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1991-05-09
1993-03-09
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 23, 514 60, 514263, 514264, A61K 3700, A61K 3170, A61K 31715, A61K 3152
Patent
active
051927403
ABSTRACT:
The invention disclosed is a composition for improving cold tolerance in animals and humans, comprising an adenosine receptor antagonist or an adenosine de-activator. Preferably, a nutritional supplement is also provided which further enhances cold tolerance. The nutritional supplement includes various combinations and amounts of carbohydrate, protein and fat.
REFERENCES:
Chem. Abstracts 106: 31620 (1987) Ogawa et al.
Chem. Abstracts 106: 27678 (1987) Tulp et al.
Chem. Abstracts 87: 127380 (1977) Foster et al.
Life Sciences. vol. 36, pp. 2025-2032, T. F. Lee et al "Improving Cold Tolerance in Elderly Rats by Aminophylline".
Interiational Journal of Biometerology, 1985, vol. 29, No. 1, pp. 37-46 Wang, "USupramaximal Heat Production Induced by Aminophylline . . . ".
Wang et al "Elicitation of supramaximal thermogenesis by aminophylline in the rat" J. Appl. Physiol: 53(1): 16-20, (1982).
Wang et al Homeostasis & Thermal Stress; Experimental & Therapeutic Advances. pp. 22-26 (Karger, Basel (1986).
Wang et al. pp. 539-547, (1986) Living in the Cold:Physiological & Biochemical Adaptations Elsevier Sci. Pub. Co. (eds-Heller et al).
Lee et al J. Therm. Biol. vol. 12, No. 2, pp. 73-76 (1987) Substrate Specificity on Enhancement of Aminophylline-Stimulated Thermogenesis.
Wang et al Life Sciences vol. 36, pp. 2539-2546 Substrate Preference in Aminophylline-Stimulated Thermogenesis (1985).
Wang Life Sciences vol. 29, pp. 2459-2466 Effects of Feeding Aminophylline Induced Ssupra Maximal Thermogenesis (1981).
Wang Modulation of maximum thermogenesis by feeding in the white rat (1980) J. Amer. Physiol 49: 975-978.
Wang et al Life Sci (1989) vol. 44, pp. 927-934 Mechanisms Underlying the Supra-Maximal Thermogenesis Elicited by Aminophylline in Rats.
Lee et al Pharmacology Bio & Behavior vol. 37 pp. 107-112 (1990) Improvement of Cold Tolerance by Selective A.sub.1 ; Adenosine Receptor . . .
Jansky Proceedings of the Symposium-Prague Apr. 1970 "Nonshivering Thermogenesis" Czechoslovak Academy of Sciences (1971) pp. 27-38.
Advances in Comparative and Environmental physiology vol. 4 Horwitz "Biochemical Mechanisms and Control of . . . Mammals" Chapt. 3 pp. 84-116.
Table 1--Effects of Carbohydrate Feeding on Cold Tolerance in Rats Bruns et al "Characterization of the A.sub.2 Adenosine . . . " Molecular.
Pedata et al "Biphasic Effect of Methylxanthines . . . " Br. J. pharmac. (1984) 83:069-073.
Mehta et al "Modulation of Vascular Tone . . . " Br. J. Pharmacol., (1992), 106: 127-132.
Lee Tze-Fun
Wang Lawrence C.
Henley III Raymond J.
University of Alberta
Waddell Frederick E.
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