Compositions and methods for immunotherapy of cancer and...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C514S002600

Reexamination Certificate

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07393534

ABSTRACT:
The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.

REFERENCES:
patent: 4444887 (1984-04-01), Hoffmann
patent: 4716111 (1987-12-01), Osband et al.
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 5122464 (1992-06-01), Wilson et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5225539 (1993-07-01), Winter
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5427908 (1995-06-01), Dower et al.
patent: 5436146 (1995-07-01), Shenk et al.
patent: 5516637 (1996-05-01), Huang et al.
patent: 5530101 (1996-06-01), Queen et al.
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5571698 (1996-11-01), Ladner et al.
patent: 5580717 (1996-12-01), Dower et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5658727 (1997-08-01), Barbas et al.
patent: 5698426 (1997-12-01), Huse
patent: 5733743 (1998-03-01), Johnson et al.
patent: 5750753 (1998-05-01), Kimae et al.
patent: 5766886 (1998-06-01), Studnicka et al.
patent: 5780225 (1998-07-01), Wigler et al.
patent: 5792644 (1998-08-01), Vermeulen et al.
patent: 5807715 (1998-09-01), Morrison et al.
patent: 5821047 (1998-10-01), Garrard et al.
patent: 5969108 (1999-10-01), McCafferty et al.
patent: 6001363 (1999-12-01), Tomley et al.
patent: 6008342 (1999-12-01), Binger et al.
patent: 6100241 (2000-08-01), Kok et al.
patent: 6331415 (2001-11-01), Lind
patent: 6407213 (2002-06-01), Carter et al.
patent: 6451984 (2002-09-01), Lillehoj et al.
patent: 6528485 (2003-03-01), Veronese et al.
patent: 239400 (1987-09-01), None
patent: 519596 (1992-12-01), None
patent: 592106 (1994-04-01), None
patent: WO 86/05807 (1987-06-01), None
patent: WO 89/01036 (1989-02-01), None
patent: WO 90/02809 (1990-03-01), None
patent: WO 91/10737 (1991-07-01), None
patent: WO 91/10741 (1991-07-01), None
patent: WO 92/04461 (1992-03-01), None
patent: WO 92/06180 (1992-04-01), None
patent: WO 91/01134 (1992-10-01), None
patent: WO 92/18619 (1992-10-01), None
patent: WO 92/20316 (1992-11-01), None
patent: WO 92/22324 (1992-12-01), None
patent: WO 92/22635 (1992-12-01), None
patent: WO 93/14188 (1993-07-01), None
patent: WO 93/15199 (1993-08-01), None
patent: WO 93/15200 (1993-08-01), None
patent: WO 93/20221 (1993-10-01), None
patent: WO 94/08598 (1994-04-01), None
patent: WO 94/12649 (1994-06-01), None
patent: WO 93/17105 (1994-12-01), None
patent: WO 95/15982 (1995-06-01), None
patent: WO 95/20401 (1995-08-01), None
patent: WO 96/33735 (1996-10-01), None
patent: WO 96/34096 (1996-10-01), None
patent: WO 97/13844 (1997-04-01), None
patent: WO 98/24893 (1998-06-01), None
patent: WO 98/46645 (1998-10-01), None
patent: WO 93/11236 (1999-03-01), None
patent: WO 98/16654 (1999-06-01), None
patent: WO 91/09967 (1999-07-01), None
patent: WO 92/01047 (1999-10-01), None
patent: WO 98/50433 (2001-05-01), None
patent: WO 01/77137 (2001-10-01), None
patent: WO 2004/020630 (2004-03-01), None
Aliberti et al. (2003), “Molecular mimicry of a CCR5 binding-clomain in the microbial activation of dendritic cells”, Nature Immunology 4(5): 485-490.
Allen & Fetterer, (2002), “Recent Advances in Biology and Immunobiology of Eimeria Species and in Diagnosis and Control of Infection with These occidian Parasites of Poultry” Clin. Microbiol. Rev. 15:58-65.
Almeida and Gazzinelli, “Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi: structural and functional analyses” J Leukoc Biol. 70(4):467-77 (2001).
Altschul et al., “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs”Nucleic Acids Res, 25(17):3389-3402, 1997.
Ames et al., “Conversion of murine Fabs isolated from a combinatoria phage display library to full length immunoglobulins” 1995, J. Immunol. Methods 184:177-186.
Ausubel et al., (eds.), “Informatics For Molecular Biologists” Current Protocols in Molecular Biology, Ch. 19 John Wiley & Sons, NY (2002).
Baca et al., “Antibody Humanization Using Monovalent Phage Display” J. Biol. Chem. 272(16):10678-84 (1997).
Bebbington and Hentschel,The use of vectors based on gene amplification for the expression of cloned genes in mammalian cellsvol. 3. (Academic Press, New York, 1987) pp. 163-189.
Better et al., “Escherichia coli Secretion of an Active Chimeric Antibody Fragment” 1988, Science 240:1041-1043.
Beverley, Cell, “Hijacking the Cell: Parasites in the Driver's Seat” 1996 87:787-789.
Bitter et al., “Expression and Secretion Vectors For Yeast”, 1987, Methods in Enzymol. 153:516-544.
Blackman & Bannister, (2001), “Apical organelles of Apicomplexa: biology and isolation by subcellular fractionation” Mol. Biochem. Parasitol. 117:11-25.
Boesen et al., “Circumvention of chemotherapy-induced myelosuppression by transfer of the mdr1 gene” 1994, Biotherapy 6:291-302.
Bout et al. “Lung Gene Therapy: In Vivo Adenovirus-Mediated Gene Transfer to Rhesus Monkey Airway Epithelium”(1994, Human Gene Therapy 5:3-10.
Brightbill et al., “Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-LikeReceptors” Science 285(5428):732-6 (1999).
Brinkman et al., “Phage display of disulfide-stabilized Fv fragments” 1995, J. Immunol. Methods 182:41-50.
Buckheit et al., “Efficacy, Pharmacokinetics, and in Vivo Antiviral Activity of UC781, a Highly Potent, Orally Bioavailable Nonnucleoside Reverse Transcriptase Inhibitor of HIV Type 1” AIDS Res. Hum. Retroviruses 1997, 13:9 pp. 789-796.
Burton et al., “Human Antibodies from Combinatorial Libraries” 1994, Advances in Immunology 57:191-280.
Cabilly et al. “Generation of antibody activity from immunoglobulin polypeptide chains produced in Escherichia coli” Proc Natl Acad Sci U S A. 81(11):3273-7 (1984).
Caldas et al., “Design and sythesis of germline-based hemi-humanized single-chain Fv against the CD18 surface antigen” Protein Eng. 13(5):353-60 (2000).
Campos et al., “Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protrozoan Parasite1” The J. Immunol. 2001, 167:416-423.
Carpenter, et al., “Antiretroviral Therapy for HIV infection in 1998” JAMA 280(1): 78-86 (1998).
Chomczynsky, P., and N. Sacchi., “Single-Step Method RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction” 1987. Anal. Biochem. 162:156-159.
Chothia et al., 1998, “Structural Determinants in the Sequences of Immunoglobulin Variable Domain” J. Mol. Biol. 278: 457-479.
Chou, P. and Fasman, G., “Prediction of Protein Conformation” 1974, Biochemistry vol. 13: No. 2 222.
Cline, “Perspectives For Gene Therapy: Inserting New Genetic Information Into Mammalian Cells By Physical Techniques And Viral Vectors” 1985, Pharmac. Ther. 29:69-92.
Clowes et al., “Long-Term Biological Response of Injured Rat Carotid Artery Seeded with Smooth Muscle Cells Expressing Retrovirally Introduced Human Genes”1994, J. Clin. Invest. 93:644-651.
Cockett et al., “High Level Expression Of Tissue Ibnhibitor Of Metalloproteinases In Chinese Hamster Ovary Cells Using Glutamine Synthetase Gene Amplification”

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