Compositions and methods for identifying modulators of TRPV2

Details Compositions and methods for identifying modulators of TRPV2 Compositions and methods for identifying modulators of TRPV2

2006-10-30

2009-08-18

Ulm, John D (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007200

Reexamination Certificate

active

07575882

ABSTRACT:
It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.

REFERENCES:
patent: 2346882 (2000-08-01), None
patent: WO 99/37675 (1999-07-01), None
patent: WO 02/069993 (2002-09-01), None
patent: WO 2005/089206 (2005-09-01), None
patent: WO 2006/005471 (2006-01-01), None
patent: WO 2006/116703 (2006-11-01), None
Hohmann A.G. et al.: “Cannabinoid Suppression of Noxious Heat-Evoked Activity in Wide Dynamic Range Neurons in the Lumbar Dorsal Horn of the Rat” Journal of Neurophysiology Feb. 1999, vol. 81, No. 2, pp. 575-583, XP002423708.
International Search Report dated Mar. 23, 2007 for Appln. No. PCT/US2006/042241.

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