Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-08
2006-08-08
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069100, C530S350000
Reexamination Certificate
active
07087388
ABSTRACT:
The invention provides cells and methods for identifying modulators of signal transduction, based on transducisome proteins that coordinate and assemble many types of signal transduction proteins. A transducisome is a PDZ domain containing protein that binds at least one signal transduction protein or a PDZ domain containing protein with at least one signal transduction protein bound. Examples of transducisome proteins include INAD, GRIP and other recently identified multi-PDZ domain proteins. Examples of signal transduction proteins include GPCRs, tyrosine kinase receptors, tyrosine phosphatase receptors, ion channels, phospholipases, adenylate cyclases, kinases and G-proteins. Also provided are methods for identifying modulators of signal transduction, proteins (and polynucleotides encoding the same) corresponding to transducisomes, modified transducisomes or defective transducisomes to use in assays of signal transduction, and a screening assay system for detecting protein-protein interactions.
REFERENCES:
patent: 6001575 (1999-12-01), Huganir et al.
patent: 6004808 (1999-12-01), Negulescu et al.
Shieh et al. 1995; Neuron 14:201-210.
Armin Huber et al, The transient receptor potential protein (Trp), a putative store-operated Ca 2+ channel essential for phosphoinositide-mediated photoreception, forms, a signaling complex with NorpA, InaC and InaD, The EMBO vol. 15 No. 24, pp. 7036-7045, 1996.
Brenman, J.E. et al., “Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains”,Cell, vol. 84, 757-767, 1996.
Cabral, J.H. et al., “Crystal structure of a PDZ domain”,Nature, vol. 382, 649-652, 1996.
Chevesich, J et al, “Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex”,Neuron, vol. 18, 95-105, 1997.
Choi, K.Y. et al., “Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating inS. cerevisiae”, Cell, vol. 78, 499-512, 1994.
Dong, H. et al., “GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors”,Naturevol. 386, 279-284, 1997.
Doyle, D.A. et al, “Crystal structure of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ”,Cell, vol. 85, 1067-1076, 1996.
Fanning, A.S. & Anderson, J.M., “Protein-protein interactions: PDZ domain networks”,Curr Biol, vol. 6, 1385-1388, 1996.
Harrison, S.C., “Peptide-surface association: the case of PD and PTB domains”,Cellvol. 86, 341-343 1996.
Kim, E. et al., “GKAP, a novel synaptic protein that interacts with the guanylate kinase-like doain of the PSD095/SAP90 family of channel clustering molecules”, J. Cell Biol, vol. 136, 669-678, 1997.
Kim, E. & Sheng, M., “Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases”,Neuropharmacology, vol. 35, 993-1000, 1996.
Larrivee, D.C. et al., “Mutation that selectively affects rhodopsin concentration in the peripheral photoreceptors of Drosophilia melanogaster”,Journal of General Physiology, vol. 78, 521-545, 1981.
Marcus, S. et al., “Complexes between STE5 and components of the pheromon-responsive mitogen-activated protein kinase module”,Proc Natl Acad Sci USA, vol. 91, 7762-7766, 1994.
Printen, J.A. & Sprague, G.J., “Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade”,Genetics, vol. 609-619, 1994.
Saras, J. & Heldin, C.H., “PDZ domains bind carboxy-terminal sequences of target proteins.”,Trendas Biochem Sci, vol. 21, 445-458, 1996.
Sato, T. et al, “FAP-1: a protein tyrosine phosphatase that associates with Fas”,Sciencevol. 268, 411-0415, 1995.
Schlessinger, J., “SH2/SH3 signaling proteins”,Curr Opin Genet Dev, vol. 4, 25-30, 1994.
Scott, K. et al, “Gaz Protein Function in vivo: Genetic Dissectio nof Its Role in Photoreceptor Cell Physiology”,Neuron, Kim, E. & Sheng, M., “Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases”,Neuropharmacology, vol. 15, 919-927, 1995.
Sheng, M., “PDZs and receptor/channel clustering: rounding up the latest suspects.”,Neuron, vol. 17, 575-578, 1996.
Shieh, B.-H. & Zhu, M.Y., “Regulation of the TRP Ca2+ channel by INAD in Drosophila photoreceptors”,Neuron, vol. 16, 991-998, 1996.
Shieh et al, “Association of INAD with NORPA is essential for controlled activation and deactivation of Drosophilia phototransduction in vivo”,Proceedings of the Natioanl Academy of Science USA, vol. 94, 12682-12687, 1997.
Songyang, Z et al, “Recognition of unique carboxyl-terminal motifs by distinct PDZ domains”,Science, vol. 275, 73-77, 1997.
Smith, D.P. et al, “Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C”,Science, vol. 254, 1478-1484, 1991.
Tsunoda et al., “A multivalent PDZ-domain protein assembles signaling complexes in a G-protein-coupled cascade”,Nature, vol. 388, 243-249, 1997.
van der Geer, P & Pawson, T., “The PTB domain: a new protein module implicated in signal transduction”,Trends Biochem Sci, vol. 20, 227-280, 1995.
Woods, D.F. & Bryant, P.J., “The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions.”,Cell, vol. 66, 451-464, 1991.
Mendlein John D.
Sierralta Jimena
Sun Yumei
Tsunoda Susan
Zuker Charles S.
Aurora Biosciences Corporation
Carlson Karen Cochrane
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