Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-10-22
2000-04-18
Ulm, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 691, 4352523, 4353201, 536 235, G01N 3353, C12N 1512
Patent
active
060513853
ABSTRACT:
The invention provides compositions a methods of identifying and testing therapeutics against HSV infection, and in particular, compositions comprising receptors which enable cell specific entry of HSV. The invention also provides a novel DNA sequence that encodes a protein B5T74 that confers the ability of herpes simplex virus (HSV) to infect and replicate in otherwise non-permissive cells. Also provided are vectors comprising the isolated nucleic acids encoding HSV receptors in host suitable for expression of the nucleic acids encoding the HSV receptors, fragments of the HSV receptors, or homologs of the HSV receptor. Further provided is a porcine cell system which expresses a herpes simplex virus receptor, but does not express endogenous, HSV entry receptors.
REFERENCES:
patent: 4430437 (1984-02-01), Hampar et al.
patent: 4642333 (1987-02-01), Person
patent: 4661349 (1987-04-01), Kino et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis et al.
patent: 4704362 (1987-11-01), Itakura et al.
patent: 4957735 (1990-09-01), Huang
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5149529 (1992-09-01), Ho et al.
patent: 5328688 (1994-07-01), Roizman
patent: 5418132 (1995-05-01), Olivo
patent: 5646155 (1997-07-01), Wright
patent: 5652096 (1997-07-01), Cimino
Montgomery et al. "Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family". Cell 87:427-436, Nov. 1996.
Morse et al., "Anatomy of Herpes Simplex Virus (HSV) DNA: X. Mapping of Viral Genes by Analysis of Polypeptides and Functions Specified by HSV-1 x HSV-2 Recombinants," J. Virol. 26:389-410 (1978).
Stevens et al., "Restriction of Herpes Simplex Virus By Macrophages," J. Exp. Med. 133:19-38 (1971).
Whitley, "Herpes Simplex Viruses," Virology, 2nd ed., Fields et. al., eds., Raven Press, N.Y., pp. 1843-1887 (1990).
Dundarov et al., "Immunotherapy With Inactivated Polyvalent Herpes Vaccines," Dev. Biol. Standard 52:351-57 (1982).
GRB Skinner et al., "Early Experience With <<Antigenoid>> Vaccine Ac NFU.sub.1 (S-) MRC Towards Prevention Or Modification Of Herpes Genitalis," Dev. Biol. Standard 52:333-44 (1982).
Chan, "Protective Immunization Of Mice With Specific HSV-1 Glycoproteins," Immunol. 49:343-52 (1983).
Stanberry et al., "Herpes Simplex Virus Glycoprotein Treatment of Recurrent Genital Herpes," J. Infect. Dis. 157:156-163 (1988).
Leib et al., "Immediate-Early Regulatory Gene Mutants Define Different Stages in the Establishment and Reactivation of Herpes Simplex Virus Latency," J. Virol. 63:759-768 (1989).
Shimeld et al., "Reactivation of Latent Infection and Induction of Recurrent Herpetic Eye Disease in Mice," J. Gen. Virol. 71:397-404 (1990).
Wigler et al., "Transformation of Mammalian Cells with an Amplifiable Dominant-Acting Gene," Proc. Natl. Acad. Sci. 77:3567-70 (1980).
Colbere-Garapin et al., A New Dominant Hybraid Selective Marker for Higher Eukaryotic Cells, J. Mol. Biol. 150:1-14 (1981).
Rhodes CA et al., "Transformation of Maize by Electroporation of Embryos," Methods Mol. Biol. 55:121-131 (1995).
Smith and Waterman, "Comparison of Biosequences," Adv. Appl. Math. 2:482-489 (1981).
Needleman and Wunsch, "A General Method Applicable to See the Search for Similarities in the Amino Acid Sequence of Two Proteins," J. Mol. Biol. 48: 443-453 (1970).
Pearson and Lipman, Improved Tools for Biological Sequence Comparison, Proc. Natl. Acad. Sci. U.S.A. 85:2444-2448 (1988).
Fuller and Spear, "Anti-Glycoprotein D Antibodies that Permit Adsorption But Block Infection By Herpes Simplex Virus 1 Prevent Virion-cell Fusion at the Cell Surface.," Proc. Natl. Acad. Sci. USA. 84:5454-5458 (1987).
DeLuca et al., "Isolation and Characterization of Deletion Mutants of Herpes Simplex Virus Type 1 in the Gene Encoding Immediate-Early Regulatory Protein ICP4," J. Virol. 56:558-570 (1985).
Wilson et al., "The Structure of an Antigenic Determinant in a Protein," Cell 37:767-778 (1984).
Zoller and Smith, "Oligonucleotide-directed Mutagenesis Using M13-Derived Vectors: An Efficient and General Procedure for the Production of Point Mutations In Any Fragment of DNA," Nuc. Acids Res. 10:6487-6500 (1982).
Harlow and Lane, Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. (1988).
Kunkel et al., "Rapid and Efficient Site-Specific Mutagenesis Without Phenotypic Selection," Methods Enzymol. 154:367-382 (1987).
Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., (1989).
Ren et al., "Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis," Cell 63:353-362 (1990).
Hogan, et al., in "Manipulating the Mouse Embryo: A Laboratory Manual," Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory (1986).
Carter et al.,"High Level Escherichia Coli Expression and Production of a Bivalent Humanized Antibody Fragment," Bio/Technology 10:163-167 (1992).
Bebbington et al.,"High-Level Expression of a Recombinant Antibody from Myeloma Cells using a glutamin Synthetase Gene as an Amplifiable Selectable Marker," Bio/Technology 10:169-175 (1992).
Montgomery et al., "Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family," Cell 87:427-436 (1996).
Fuller, "Microbes and the Proteoglycan Connection," J. Clin. Invest. 93:460 (1994).
Fuller and Lee, "Herpes Simplex Virus Type 1 Entry through a Cascade of Virus-Cell Interactions Requires Different Roles of gD and gH in Penetration," J. Virol. 66:5002-5012 (1992).
Subramanian et al., "Swine Testis Cells Contain Functional Heparan Sulfate but Are Defective in Entry of Herpes Simplex Virus," J. Virol. 68:5667-5676 (1994).
Subramanian et al., "Defective entry of herpes simplex virus types 1 and 2 into porcine cells and lack of infection in infant pigs indicate species tropism," J. Gen. Virol. 76:2375-2379 (1995).
Marsters et al., "Herpesvirus Entry Mediator, a Member of the Tumor Necrosis Factor Receptor (TNFR) Family, Interacts with Members of the TNFR-associated Factor Family and Activates the Transcription Factors NF-.kappa.B and AP-1," J. Biol. Chem. 272:14029-14032 (1997).
Shieh et al., "Cell Surface Receptors for Herpes Simplex Virus Are Heparan Sulfate Proteoglycans," J. Cell Biol. 116:1273-1281 (1992).
Fuller A. Oveta
Li Qing-xue
McLaren Ning-hun C.
Perez Aleida
Subramanian Gangadharan
The Regents of the University of Michigan
Ulm John
LandOfFree
Compositions and methods for identifying and testing therapeutic does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for identifying and testing therapeutic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for identifying and testing therapeutic will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2335336