Compositions and methods for identification and use of soluble c

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 71, 435 792, 435 794, 530350, 5303871, 53038885, 5303879, 5303881, 5303891, G01N 3353, G01N 33541, G01N 3368, C07K 1618

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056100213

ABSTRACT:
Disclosed are novel compositions of osteogenic proteins constituting soluble forms of these proteins, and methods and compositions for distinguishing between soluble and mature forms of these proteins.

REFERENCES:
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Celeste, A. J. et al, PNAS, 87:9843-9847, Dec. 1990.
Doctor et al., "Sequencing, Biochemical Characterization, and Developmental Expression of a New Member of the TGF-.beta. Superfamily in Drosophila melanogaster", Developmental Biology, 151:491-505 (1992).
Sauermann et al., "Cloning of a Novel TGF-.beta. Related Cytokine, the vgr, From Rat Brain: Cloning of and Comparison to Homologous Human Cytokines", Journal of Neuroscience Research, 33:142-147 (1992).
Rosen et al., "The BMP proteins in bone formation and repair", Reviews, 8:97-102 (1992).
Wang et al., "Recombinant Human Bone Morphogenetic Protein Induces Bone Formation" Proc. Natl. Acad. Sci. 87:2220-2224 (1990).

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