Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-09-25
2007-09-25
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200
Reexamination Certificate
active
10411915
ABSTRACT:
The subject invention relates to nucleic acid sequences for detection of mutations in a PKD-1 or PKD-2 gene, as well as biomarkers for ADPKD. The invention further relates to methods for diagnosing ADPKD in an individual, and kits for performing the methods of the invention. The invention also provides a method for determining in an individual the presence or absence of a mutant PKD gene.
REFERENCES:
patent: 5891628 (1999-04-01), Reeders et al.
patent: 6031088 (2000-02-01), Somlo et al.
patent: 6071717 (2000-06-01), Klinger et al.
patent: 6228591 (2001-05-01), Somlo et al.
patent: 6656681 (2003-12-01), Harris et al.
patent: 2003/0008288 (2003-01-01), Germino et al.
patent: WO 02/06529 (2002-01-01), None
Inoue et al., Human Mutation 19, 622-628 (May 3, 2002).
Aguiari et al., American Journal of Kidney Diseases 33(5), 880-885 (1999).
Phakdeekitcharoen, B. et al., (2001), “Mutation Analysis of the Entire Replicated Portion ofPKD1Using Genomic DNA Samples”,J. Am. Soc. Nephrol, 12:955-963.
Perrichot, R.A. et al., (1999), “DGGE screening ofPKD1gene reveals novel mutations in a large cohort of 146 unrelated patients”,Hum. Genet., 105:231-239.
Thomas, R. et al., (1999), “Identification of Mutations in the Repeated Part of the Autosomal Dominant Polycystic Kidney Disease Type 1 Gene, PKD1, by Long-Range PCR”,Am. J. Hum. Genet., 65:39-49.
Watnick, T. et al., (1999), “Mutation Detection ofPKD1Identifies a Novel Mutation Common to Three Families with Aneurysms and/or Very-Early-Onset Disease”,Am. J. Hum. Genet., 65:1561-1571.
Watnick, T.J. et al., (1998), “Somatic Mutation in Individual Liver Cysts Supports a Two-Hit Model of Cystogenesis in Autosomal Dominant Polycystic Kidney Disease”,Molecular Cell, 2:247-251.
Roelfsema, J.H. et al., (1997), “Mutation Detection in the Repeated Part of the PKD1 Gene”,Am. J. Hum. Genet., 61:1044-1052.
Watnick, T.J. et al., (1997), “An unusual pattern of mutation in the duplicated portion ofPKD1is revealed by use of a novel strategy for mutation detection”,Human Molecular Genetics, 6(9):1473-1481.
Neophytou, P. et al., (1996), “Detection of a novel nonsense mutation and an intragenic polymorphism in he PKD1 gene of a Cypriot family with autosomal dominant polycystic kidney disease”,Hum. Genet., 98:437-442.
Peral, B. et al., (1996), “Screening the 3′ Region of the Polycystic Kidney Disease 1 (PKD1) Gene Reveals Six Novel Mutations”,Am. J. Hum. Genet., 58:86-96.
Turco, A.E. et al., (1995), “A novel nonsense mutation in the PKD1 gene (C3817T) is associated with autosomal dominant polycystic kidney disease (ADPKD) in a large three-generation Italian family”,Human Molecular Genetics, 4(8):1331-1335.
Ward, C.J. et al., (1995), “Homo sapienspolycystic kidney disease-associated protein (PKD1) gene, complete cds”, DatabaseEMBLOnline, Database Accession No. L39891:1-20.
International Search Report of International Application No. PCT/US01/22035.
Rossetti, s. et al., “Mutation Analysis of the Entire PKD1 Gene: Genetic and Diagnostic Implications”, 2001,Am. J. Hum. Genet., 68:46-63.
Underhill, P.A. et al., “Detection of Numerous Y Chromosome Biallelic Polymorphisms by Denaturing High-Performance Liquid Chromatography”, 1997,Genome Research, 7:996-1005.
Liu, W. et al., “Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations”, 1998,Nucleic Acids Research, 26(6):1396-1400.
Allen Susan K.
Curran John A.
Flynn Kerry E.
Garcés Jorge A.
Hennigan Aidan N.
Athena Diagnostics, Inc.
Hamilton Brook Smith & Reynolds P.C.
Horlick Kenneth R.
LandOfFree
Compositions and methods for genetic analysis of polycystic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for genetic analysis of polycystic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for genetic analysis of polycystic... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3750081