Compositions and methods for functionalizing nucleic acids

Details Compositions and methods for functionalizing nucleic acids Compositions and methods for functionalizing nucleic acids

1985-06-13

1988-08-09

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 91, 536 27, 536 28, 536 29, C12Q 168, C12P 1934, C07H 1512

Patent

active

047627794

ABSTRACT:
A composition and a method for 5'-labelling polynucleotides undergoing solid phase synthesis wherein a phosphoramidite of an .omega.-hydroxylamine is condensed to a support-bound polynucleotide.

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Bauman et al., Histochem. Cytochem., 29, 227-237, (1981).
Broker et al., Nucleic Acids Res., 5, 363-384, (1978).
Chollet et al., Nucleic Acids Res., 13, 1529-1541, (1985).
Cuatrecasas, J. Biol. Chem., 245(12), 3059-3065, (1970).
Kempe et al., Nucleic Acids Res., 13, 45-57, (1985).
McBride et al., Tetrahedron Letters, 24, 245, (1983).
Maniatis et al., Cell, 15, 687, (1978).
Manning et al., Chromosoma (Berl.), 53, 107-117, (1975).
Richards et al., Proc. Natl. Acad. Sci. (U.S.A.), 76, 676-680, (1979).
Watson et al., Science, 218, 381-384, (1982).

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