Compositions and methods for exon profiling

Details Compositions and methods for exon profiling Compositions and methods for exon profiling

2000-11-28

2010-10-05

Lu, Frank W (Department: 1634)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S006120, C435S091100, C435S091510, C435S287100, C536S023100, C536S024300, C536S024330

Reexamination Certificate

active

07807447

ABSTRACT:
The present invention provides methods for analyzing exon expression profiles of a cell or type of cell. In the invention, the expression levels of a plurality of individual exons or multiexons for each of a plurality of genes in the genome of an organism are measured and analyzed to determine the biological state, such as the exon expression state or transcriptional state, of the cell or type of cell. The methods of the invention are useful for determination of alternative RNA splicing in a plurality of genes. The invention also provides nucleic acid probe arrays for determining in parallel the expression levels of a plurality of exons or multiexons for each of a plurality of genes in the genome of an organism. The invention further provides methods for determining the effects of perturbations, such as perturbations by drugs, on exon expression and alternative RNA splicing pathways.

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