Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-01-09
2008-08-05
Kim, Young J. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
07407760
ABSTRACT:
The present invention provides compositions, methods and kits for enhancing the amplification of PrPScfor use in increasing the sensitivity of identifying the presence of PrPScin a sample.
REFERENCES:
patent: 6670328 (2003-12-01), Lassalle et al.
patent: 2002/0137114 (2002-09-01), Voelkel et al.
Saborio et al. (“Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding” Nature. Jun. 14, 2001;411(6839):810-3).
Saborio et al. (“Cell-lysate conversion of prion protein into its protease-resistant isoform suggests the participation of a cellular chaperone” Biochem Biophys Res Commun. May 10, 1999;258(2):470-5).
Bessen et al., “Non-genetic propagation of strain-specific properties of scrapie prior protein”, Nature 1995 375:698-700.
Brimacombe et al., “Characterization and polyanion-binding properties of purified recombinant prior protein”, Biochem. J. 1999 342:605-613.
Brown et al., “Consequences of manganese replacement of copper for prion protein function and proteinase resistance”, The EMBO Journal 2000 19 (6) :1180-1186.
Caughey, B., “Formation of Protease-Resistant Prion Protein in Cell-free Systems”, Curr. Issues Mol. Biol. 2000 2 (3) :95-101.
Cordeiro et al., “DNA Converts Cellular Prion Protein into the β-Sheet Conformation and Inhibits Prion Peptide Aggregation”, J. Biol. Chem. 2001 276 (52) :49400-49409.
Derrington et al., “PrPchas nucleic acid chaperoning properties similar to the nucleocapsid protein of HIV-1”, C.R. Biologies 2002 325:17-23.
Gabus et al., “The Prion Protein Has RNA Binding and Chaperoning Properties Characteristic of Nucleocapsid Protein NCp7 of HIV-1”, J. Biol. Chem. 2001 276 (22) :19301-19309.
Gabus et al., “The Prion Protein has DNA Strand Transfer Properties Similar to Retroviral Nucleocapsid Protein”, J. Mol. Biol. 2001 307:1011-1021.
Horiuchi et al., “Specific binding of normal prion to the scrapie form via a localized domain initiates its conversion to the protease-resistant state”, The EMBO Journal 1999 18 (12) :3193-3203.
Horiuchi et al., “Prion protein interconversions and the transmissible spongiform encephalopathies”, Structure 1999 7 (10) :R231-R240.
Kocisko et al., “Species specificity in the cell-free conversion of prion protein to protease-resistant forms:A model for the scrapie species barrier”, Proc. Natl. Acad. Sci. USA 1995 92:3923-3927.
Kocisko et al., “Cell-free formation of protease-resistant prion protein”, Nature 1994 370:471-474.
Moscardini et al., “Functional Interactions of Nucleocapsid Protein of Feline Immunodeficiency Virus and Cellular Prion Protein with the Viral RNA”, J. Mol. Biol. 2002 318:149-159.
Nandi et al., “DNA-induced Partial Unfolding of Prion Protein Leads to its Polymerisation to Amyloid”, J. Mol. Biol. 2002 322:153-161.
Nandi et al., “Unusual Property of Prion Protein Unfolding in Neutral Salt Solution”, Biochemistry 2002 41:11017-11024.
Proske et al., “Prion-Protein-Specific Aptamer Reduces PrPScFormation”, ChemBioChem 2002 3:717-725.
Saborío et al., “Cell-Lysate Conversion of Prion Protein into Its Protease-Resistant Isoform Suggests the Participation of a Cellular Chaperone”, Biochemical and Biophysical Research Communications—1999 258:470-475.
Warner et al., “Identification of the Heparan Sulfate Binding Sites in the Cellular Prion Protein”, J. Biol. Chem. 2002 277 (21) :18421-18430.
Weiss et al., “RNA Aptamers Specifically Interact with the Prion Protein PrP”, Journal of Virology 1997 71 (11) :8790-8797.
Zeiler et al., “Concentration and removal of prion proteins from biological solutions”, Biotechnol. Appl. Biochem. 2003 37:137-182.
Deleault Nathan
Supattapone Surachai
Babic Christopher M.
Kim Young J.
Licata & Tyrrell P.C.
Trustees of Dartmouth College
LandOfFree
Compositions and methods for enhancing the identification of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for enhancing the identification of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for enhancing the identification of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3993348