Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reissue Patent
2007-06-21
2010-12-28
Azpuru, Carlos A (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S423000, C424S434000, C424S451000, C424S464000
Reissue Patent
active
RE042012
ABSTRACT:
Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
REFERENCES:
patent: 4013792 (1977-03-01), Eichman et al.
patent: 4383993 (1983-05-01), Hussain et al.
patent: 4749700 (1988-06-01), Wenig
patent: 4810503 (1989-03-01), Carson et al.
patent: 4956171 (1990-09-01), Chang
patent: 5013714 (1991-05-01), Lindstrom
patent: 5120546 (1992-06-01), Hansen et al.
patent: 5258499 (1993-11-01), Konigsberg et al.
patent: 5344644 (1994-09-01), Igari et al.
patent: 5399351 (1995-03-01), Leshchiner et al.
patent: 5442043 (1995-08-01), Fukuta
patent: 5766620 (1998-06-01), Heiber et al.
patent: 5985320 (1999-11-01), Edwards et al.
patent: 6387390 (2002-05-01), Deaver et al.
patent: 6652873 (2003-11-01), Deaver et al.
patent: 6908623 (2005-06-01), Deaver et al.
patent: 0267015 (1988-05-01), None
patent: 0312208 (1989-04-01), None
patent: 0 391 342 (1990-10-01), None
patent: 1090492 (1967-11-01), None
patent: 1 090 492 (1967-11-01), None
patent: WO 83/01198 (1983-04-01), None
patent: WO 86/02553 (1986-05-01), None
patent: WO 87/02576 (1987-05-01), None
patent: WO 89/05149 (1989-06-01), None
patent: WO 92/11037 (1992-07-01), None
patent: WO 92/11037 (1992-07-01), None
patent: WO 93/08845 (1993-05-01), None
patent: WO 94/00155 (1994-01-01), None
patent: WO 96/05321 (1996-02-01), None
patent: WO 96/10335 (1996-04-01), None
patent: WO 97/32572 (1997-09-01), None
Barzu, et al., “Endothelial binding sites for heparin. Specificity and role in heparin neutralization,”Biochem J.238(3):847-54 (1986).
Concise Encyclopedia of Polymer Science and Polymeric Amines and Ammonium Salts,(Goethals, ed.) (Pergamen Press, Elmsford, NY, 1980).
Counis, et al., “Gonadotropin-releasing hormone and the control of gonadotrope function”,Reprod. Nutr. Dev.,45:243-254 (2005).
Deaver, et al., “Effects of domperidone and thyrotropin-releasing hormone on secretion of luteinizing hormone and prolactin during the luteal phase and following induction of luteal regression in sheep,”Domes. Amin. Endocrinol.4(2):95-102 (1987).
Edwards, et al., “Spontaneous vesicle formation at lipid bilayer membranes,”Biophys J.71(3):1208-14 (1996).
Edwards, et al., “The nucleation of receptor-mediated endocytosis,”PNAS USA93(5):1786-91 (1996).
Evans & Yeung, “Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspiration,”Biophys J56(1):151-60 (1989).
Goldstein, et al., “Receptor-mediated endocytosis: concepts emerging from LDL receptor system,”Annu Rev Cell Biol1:1-39 (1985).
Illum, et al., “Bioadhesive microspheres as a potential nasal drug delivery system,”Int J Pharm39:189-199 (1987).
Lopata, et al., “High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment”,Nucleic Acids Research,12(14): 5707-5717 (1984).
Mandal, et al., “Physiochemical studies on achatininH, a novel sialic acid-binding lectin,”Biochem J257(1):65-71 (1989).
McCutchen and Pagano, “Enhancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran”,Journal of the National Cancer Institute,41:351-357 (1986).
McGraw, et al., “Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferring receptors”,J. Cell Biol.,105:207-214 (1987).
Pagano, “Lipid traffic in eukaryotic cells: mechanisms for intracellular transport and organelle-specific enrichment of lipids,”Curr Opin Cell Biol2(4):652-63 (1990).
Rodman, et al., “Endocytosis and transcytosis,”Curr Opin Cell Biol2(4):664-72 (1990).
Scartazzini, et al., “Organogels from lecithins”,Phys. Chem.,92:829-833 (1988).
Schmid, “Biochemical requirements for the formation of clathrin- and COP-coated transport vesicles,”Curr Opin Cell Biol5(4):621-7 (1993).
Schonhorn and Wesslin-Resnick, “Brefeldin A down-regulates the transferring receptor in K562 cells”,Molecular and Cellular Biochem.,135:159-169 (1994).
Sheetz & Dai, “Modulation of membrane dynamics and cell motility by membrane tension,”60th Annual Cold Spring Harbor Symposium on Protein Kinases,Cold Spring Harbor, N.Y. (1995).
Smythe, et al., “Formation of coated vesicles from coated pits in broken A431 cells,”J Cell Biol108(3):843-53 (1989).
Smythe, et al., “Cytosol- and clathrin-dependent stimulation of endocytosis in vitro by purified adaptors,”J Cell Biol119(5):1163-71 (1992).
Trowbridge, “Endocytosis and signals for internalization,”Curr Opin Cell Biol3(4):634-41 (1991).
Wang, et al., “Mechanotransduction across the cell surface and through the cytoskeleton,”Science260(5111):1124-7 (1993).
Wang, et al., “Control of cytoskeletal mechanics by extracellular matrix,”Biophys. J.,66:2181-2189 (1994).
Wright & Detmers, “Receptor-mediated phagocytosis” inThe Lung: Scientific Foundations(Crystal, et al., eds.), pp. 539-549 (Ravens Press, Ltd., New York, NY (1991).
McCutchan and Pagano, “Enhancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran”,Journal of the National Cancer Institute,XP009007119, 41:351-357 (1986).
Deaver Daniel R.
Edwards David A.
Langer Robert S.
Azpuru Carlos A
Massachusetts Institute of Technology
Pabst Patent Group LLP
The Penn State Research Foundation
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