Compositions and methods for enhancing immune responses...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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C424S185100, C424S192100

Reexamination Certificate

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10856455

ABSTRACT:
Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand functionally linked to an immunogen, e.g. tumor associated antigens, bacterial or viral antigens, etc. Methods are disclosed for delivery of these molecular adjuvants to patients, resulting in the transduction of activating signals to the targeted antigen presenting cell, thereby enhancing the immune response to the co-delivered immunogen.

REFERENCES:
patent: 4950480 (1990-08-01), Barber et al.
patent: 5032401 (1991-07-01), Jamas et al.
patent: 5073627 (1991-12-01), Curtis et al.
patent: 5696230 (1997-12-01), Sanderson et al.
patent: 5804187 (1998-09-01), do Couto et al.
patent: 6248332 (2001-06-01), Romet-Lemonne et al.
patent: 2 177 514 (1983-10-01), None
patent: WO 92/05793 (1992-04-01), None
patent: WO 92/11031 (1992-07-01), None
patent: WO 93/10814 (1993-06-01), None
patent: WO 95/25957 (1995-09-01), None
Campbell, 1984, Monoclonal Antibody Technology, Elsevier Sciences, p. 1-32.
Kuby, Immunology, 1994, 2nded. p. 123, WH Freeman and Co.
Kuby, Immunology, 2ndEd. 1994, p. 89-91, 297-306.
Tempero, R.M., et al., “Molecular Adjuvant Effects of a Conformationally Biased Agonist of Human C5a Anaphylatoxin”, J. Immunology, vol. 158:1377-1382 (1997).
Baier, G., et al., “Immunogenic Targeting of Recombinant Peptide Vaccines to Human Antigen-Presenting Cells by Chimeric Anti-HLA-DR and Anti-Surface Immunoglobulin D Antibody Fab Fragments In Vitro”, J. Virology, vol. 69: 2357-2365 (1995).
Grosjean, I. et al., “CD23/CD21 Interaction is Required for Presentation of Soluble Protein Antigen by Lymphoblastoid B Cell Lines to Specific CD4+ T Cell Clones,” Eur. J. Immuol. (1994) 24(12):2982-2986 [ABSTRACT].

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