Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-06-12
2007-06-12
Russel, Jeffrey Edwin (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S011400, C514S016700, C514S263380, C514S634000, C514S636000
Reexamination Certificate
active
10083960
ABSTRACT:
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length (SEQ ID NO:86).
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Kirschberg Thorsten A.
McGrane P. Leo
Rothbard Jonathan B.
Sista Lalitha V. S.
Wender Paul A.
Cellgate, Inc.
Morrison & Foerster / LLP
Russel Jeffrey Edwin
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