Compositions and methods for enhancing corticosteroid delivery

Details Compositions and methods for enhancing corticosteroid delivery Compositions and methods for enhancing corticosteroid delivery

2007-05-22

2007-05-22

Hui, San-Ming (Department: 1617)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

C514S171000, C514S180000, C514S169000

Reexamination Certificate

active

10407380

ABSTRACT:
The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70.

REFERENCES:
patent: 3934013 (1976-01-01), Poulsen
patent: 0 020 794 (1981-01-01), None
patent: WO 91/08733 (1991-06-01), None
Physicians' Desk Reference, 51 Edition, pp. 2299-2300, for example.
Bennett et al., “Optimization of bioavailability of topical steroids: non-occluded penetration enhancers under thermodynamic control”, Journal of Pharmacy and Pharmacology, vol. 37, No. 5, 1985, pp. 298-304.

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