Compositions and methods for enhanced mucosal delivery of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C424S450000, C514S058000

Reexamination Certificate

active

11126996

ABSTRACT:
Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.

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Codrons, V.; Vanderbist, F.; Verbeeck, R. K.; Arras, M.; Lison, D.; Preat, V.; and Vanbever, R.; “Systemic Delivery of Parathyroid Hormone (1-34) Using Inhalation Dry Powders in Rats;”J Pharm Sci; May 2003; 92 (5): 938-950.
Newman, S. P.; Pitcairn, G. R.; and Dalby, R. N.; “Drug Delivery to the Nasal Cavity: in Vitro and in Vivo Assessment;”Crit Rev. Ther Drug Carrier Syst; 2004; 21 (1); 21-66.

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