Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-10-26
2010-02-16
Marvich, Maria B (Department: 1633)
Chemistry: molecular biology and microbiology
Vector, per se
C435S069100, C536S023100, C536S023530, C536S024100, C536S024200
Reexamination Certificate
active
07662623
ABSTRACT:
Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo.
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Fang Jianmin
Jooss Karin
Qian Jing-Jing
Simmons Andrew
BioSante Pharmaceuticals, Inc.
Chen Teresa A.
Haley Jr. James F.
Marvich Maria B
Ropes & Gray LLP
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