Compositions and methods for drug delivery using pH...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S458000, C536S023100

Reexamination Certificate

active

10083456

ABSTRACT:
A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell.

REFERENCES:
patent: WO 96/37194 (1996-11-01), None
patent: WO 96/41616 (1996-12-01), None
patent: WO 97/05266 (1997-02-01), None
patent: WO 98/19710 (1998-05-01), None
Metrikin et al., “Intravitreal drug administration with depot devices,” Current Opinion in Ophthalmology; 1994, vol. 5, pp. 21-29.
Duzgunes et al., “pH-sensitive liposomes,” California Biotechnology; pp. 113-131.
Hu et al., “Characterization of norfloxacine release from tablet coated with a new ph-sensitive polymer, p-4135f,” Journal of Drug Targeting; 1999, vol. 7, No. 3, pp. 223-232.
Hawley-Nelson et al., “Lipofectamine reagent: a new, higher efficiency polycationic liposome transfection reagent,” Focus; vol. 15, No. 3, pp. 73-79.
Kirby, “Effective Molarities for intramolecular reactions,” University Chemical Laboratory, Cambridge, England; pp. 187-278.
Legendre et al., “Delivery of Plasmid DNA into mammalian Cell Lines using ph-sensitive liposomes: comparison with cationic liposomes,” Pharmaceutical Research; 1992, vol. 9, No. 10, pp. 1235-1241.
Sezaki et al., “Soluble macromolecular carriers for the delivery of antitumour drugs,” Elsevier Science Publishers; 1989pp. 247-266.
Jain et al., “Controlled drug delivery by biodegradable poly9ester0devices: different preparative approaches,” Drug Development and Industrial Pharmacy; 1998, vol. 24, No. 8, pp. 703-727.
Berton et al., “Uptake of oligonucleotide-loaded nanoparticles in prostatic cancer cells and their intracellular localization,” European Journal of Pharmaceutics and Biopharmaceutics; 1999, vol. 47, pp. 119-123.
Gerweck et al., “Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer,” Cancer Research; Mar. 15, 1996, vol. 56, pp. 1194-1198.
Thorpe et al., “Comparison of two anti-thy 1.1-abrin a-chain immunotoxins prepared with different cross-linking agents: antitumor effects, in vivo fate, and tumor cell mutants,” JNCI; Nov. 1987, vol. 79, No. 5, pp. 1101-1111.
Gill et al., “Calculation of protein extinction coefficients from amino acid sequence data,” Analytical Biochemistry; 1989, vol. 182, pp. 319-326.
Felgner et al., “Lipofection: a highly efficient, lipid-mediated dna-transfection procedure,” Proc. Natl. Acad. Sci. Usa; Nov. 1987, vol. 84, pp. 7413-7417.
Lowman et al., “Oral delivery of insulin using pH-responsive complexation gels,” Journal of Pharmaceutical Science; Sep. 1999, vol. 88, No. 9, pp. 933-937.
Ohmori et al., “The Enhancing effect of anionic a-Helical peptide on cationic peptide-mediating transfection systems,” Biochemical and Biophysical Research Communications; 1997, vol. 235, pp. 726-729.
Madsen et al., “Complexation graft copolymer networks: swelling properties, calcium binding and proteolytic enzyme inhibition,” Biomaterials; 1999, vol. 20, pp. 1701-1708.
Zauner et al., “Rhinovirus-mediated endosomal release of transfection complexes,” Journal of Virology; Feb. 1995, vol. 69, No. 2, pp. 1085-1092.
Zhou et al., “DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action,” Biochimica et Biophysics Acta; 1994, vol. 1189, pp. 195-203.
Zhou et al., “Lipophilio polylysines mediate efficient DNA transfection in mammalian cells,” Biochimica et Biophysics Acta; 1991, vol. 1065, pp. 8-14.
Seetharam et al., “Increased cytotoxic activity ofPseudomonas exotoxinand two chimerie toxins ending in kdel,” The Journal of Biological Chemistry; Sep. 15, 1991, vol. 266, No. 26, pp. 17376-17381.
Senior et al., “Interaction of positively-charged liposomes with blood: implications for their application in vivo,” Biochimica et Biophysica Acta; 1991, vol. 1070, pp. 173-179.
Pastan et al., “Pseudomonas exotoxin: chimeric toxins” The Journal of Biological Chemistry; Sep. 15, 1989, vol. 264, No. 26, pp. 15157-15160.
Perez et al., “Comonomer sequence assignment of the Cn.m.r. spectra of some ply(epichlorohydrin) derivatives obtained by nucleophilic substitution,” Polymer; 1998, vol. 39, No. 17, pp. 3885-3892.
Nishikubo et al., “Degradation of dehydrochlorinated ly(epichlorohydrin) using photo-generated cationic catalysts,” Polymer Science: Part A: Polymer Chemistry; 1986, vol. 24, pp. 1097-1108.
Mechtler et al., “Gene transfer mediated by influenza virus peptides: the role of peptide sequences,” New Journal of Chemistry; 1997, vol. 21, pp. 105-111.
Kishore et al., “Polymers containing disulfide, tetrasulfide, diselenide and ditelluride linkages in the main chain,” Advances in Polymer Sciences; 1995, vol. 121.
Kichler et al., “Efficient gene delivery with neutral complexes of lipospermine and thiol-reactive phospholipids,” Biochemical and Biophysical Research Communications; 1995, vol. 209, No. 2, pp. 444-450.
Wolff et al., “Direct gene transfer into mouse muscle in vivo,” Science; 1990, vol. 247, pp. 1465-1468.
Wolfert et al., “Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block co-polymers,” Human Gene Therapy; Nov. 1996, vol. 7, pp. 2123-2133.
Wagner et al., “Delivery of drugs, proteins and genes into cells using transferring as a ligand for receptor-mediated endocytosis,” Advanced Drug Delivery Reviews; 1994, vol. 14, pp. 113-135.
Wagner et al., “Influenza virus hemagglutinin ha-2 n-terminal fusogenic peptides augment gene transfer by transferring-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle,” Proc. Natl. Acad. Sci.; Sep. 1992, vol. 89, pp. 7934-7938.
Wetering et al., “Copolymers of 2-(dimethylamino)ethyl methacrylate with ethoxyriethylene glycol methacrylate or n-vinyl-pyrrolidone as gene transfer agents,” Journal of Controlled Release; 2000, vol. 64, pp. 193-203.
Trubetskoy et al., “Self-assembly of DNA-polymer complexes using template polymerization,” Nucleic Acids Research; 1998, vol. 26, No. 18, pp. 4178-4185.
Trubetskoy et al., “Quantitative Assessment of DNA Condensation,” Analytical Biochemistry; 1999, vol. 267, pp. 1-5.
Trubetskoy et al., “Layer-by-layer deposition of oppositely charged polyelectrolytes on the surface of condensed DNA particles,” Nucleic Acids Research; 1999, vol. 27, No. 15, pp. 3090-3095.
Trubetskoy et al., “Caged DNA does not aggregate in high ionic strength solutions,” Bioconjugate Chem.; 1999, vol. 10, pp. 624-628.
Seymour et al., “Polymer Chemistry” polymer chemistry.
Remy et al., “Gene Transfer with a series of lipophilic DNA-binding molecules,” Bioconjugate Chem.; 1994, vol. 5, pp. 647-654.
Remy et al., “Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artifidial viruses,” Proc. Natl. Acad. Sci.; Feb. 1995, vol. 92, pp. 1744-1748.
O'Brien-Simpson et al., “Polymerization of Unprotected Synthetic Peptides: A View toward Synthetic Peptide Vaccines,” J. Am. Chem. Soc.; 1997, vol. 119, pp. 1183-1188.
Murthy et al., “The design and synthesis of polymers for eukaryotic membrane disruption,” Journal of Controlled Release; 1999, vol. 61, pp. 137-143.
Meyer et al., “Copolymers of N-isopropylacrylamide can trigger pH sensitivity to stable liposomes,” FEBS Letters; 1998, vol. 421, pp. 61-64.
Kresge et al., “Vinyl ether hydrolysis. 9. isotope effects on proton transfer from the hydronium ion,” Journal of the American Chemical Society; Oct. 1977, vol. 99, No

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions and methods for drug delivery using pH... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for drug delivery using pH..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for drug delivery using pH... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3739899

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.