Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-08-30
2011-08-30
Nguyen, Quang (Department: 1633)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S006120, C435S320100, C435S455000
Reexamination Certificate
active
08008463
ABSTRACT:
The present disclosure relates to RFX4_v3 protein and nucleic acids encoding the RFX4_v3 protein. The present disclosure provides non-human transgenic animals with altered RFX4_v3 genes, and provides assays for the detection of RFX4_v3 and RFX4_v3 polymorphisms associated with disease states. The present disclosure additionally provides methods of determining a subjects' risk of developing congenital hydrocephalus, and treating or inhibiting its development.
REFERENCES:
patent: 6812339 (2004-11-01), Venter et al.
patent: 6828097 (2004-12-01), Knoll et al.
patent: 7560542 (2009-07-01), Andersen et al.
patent: 2003/0180298 (2003-09-01), Old et al.
patent: WO 84/03564 (1984-09-01), None
patent: WO02/086071 (2002-10-01), None
Araki et al. Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus. J. Biol. Chem. 279:10237-10242, 2004.
Griffin et al. t(11;18)(q21;q21) is a recurrent chromosome abnormality in small lymphocytic lymphoma. Genes, Crhomosimes & Cancer 4:153-157, 1992.
Attwood, T.K. The Babel of Bioinformatics. Science 290:471-473, 2000.
Kyrpides et al. Whole-genome sequence annotation: “Going wrong with confidence”. Mol. Microbiology 32:886-887, 1999.
Wells et al. The chemokine information source: Identification and characterization of novel chemokines using the WoridWideWeb and Expressed sequence tag databases. J. Leukoc. Biol. 61:545-550, 1997.
Gerhold et al. It's the genes! EST access to human genome content. BioEssays 18:973-981, 1996.
GenBank Accession No. BB611382.1, Oct. 26, 2001; pp. 1-3.
Brümmendorf et al., “Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations,”Current Opinion in Neurobiology8:87-97, 1998.
Gajiwala et al., “Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding,”Nature, 403:916-921, 2000.
Morotomi-Yano et al., “Human Regulatory Factor X 4 (RFX4) Is a Testis-specific Dimeric DNA-binding Protein That Cooperates with Other Human RFX Members,”J. Biol. Chem. 277(1):836-842, 2002.
Pérez-Fígares et al., “Subcommissural Organ, Cerebrospinal Fluid Circulation, and Hydrocephalus,”Microscopy Research and Technique52:591-607, 2001.
GenBank Accession No. AF332192, Mar. 11, 2001.
GenBank Accession No. BAC28598, Dec. 5, 2002.
GenBank Accession No. NM—032491, Apr. 6, 2003.
GenBank Accession No. NP—002911, Apr. 6, 2003.
GenBank Accession No. NT—009720, May 8, 2002.
GenBank Accession No. XP—125797, Feb. 24, 2003.
Blackshear et al., “Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4,”Development130(19):4539-4552, 2003.
Dotzlaw et al., “Characterization of estrogen receptor variant mRNAs from human breast cancers,”Mol. Endocrinol. 6:773-785, 1992.
Miao et al., “Isolation of an allele of reeler by insertional mutagenesis,”Proc. Natl. Acad. Sci. USA91(23):11050-11054, 1994.
GenBank Accession No. AA285775, Apr. 9, 1997, 2 pages.
GenBank Accession No. AAK17191, Mar. 11, 2001, 2 pages.
GenBank Accession No. AI462920, Mar. 9, 1999, 2 pages.
GenBank Accession No. AI657628, Jun. 7, 2001, 2 pages.
GenBank Accession No. AK034131, Apr. 3, 2004, 4 pages.
GenBank Accession No. AY102009, Aug. 19, 2003, 3 pages.
GenBank Accession No. AY102010, Sep. 26, 2003, 3 pages.
GenBank Accession No. AY102011, Aug. 19, 2003, 3 pages.
GenBank Accession No. BB379807, Oct. 24, 2001, 3 pages.
GenBank Accession No. BB595996, Oct. 26, 2001, 3 pages.
GenBank Accession No. BB873367, Nov. 27, 2001, 2 pages.
GenBank Accession No. H10145, Jun. 23, 1995, 2 pages.
GenBank Accession No. NM—000775, Dec. 20, 2004, 4 pages.
GenBank Accession No. NM—002920, Oct. 27, 2004, 3 pages.
GenBank Accession No. NP—115880, Oct. 28, 2004, 2 pages.
GenBank Accession No. NT—035235, Apr. 10, 2003, 2 pages.
GenBank Accession No. NT—039498, Feb. 24, 2003, 6 pages.
GenBank Accession No. U71441, Oct. 21, 1996, 3 pages.
NCBI Trace Archive No. gnl/ti/13973384.
NCBI Trace Archive No. gnl/ti/84074979.
NCBI Trace Archive No. gnl/ti/91911671.
Blackshear Perry J.
Graves Joan P.
Stumpo Deborah J.
Zeldin Darryl C.
Klarquist Sparkman LLP.
Nguyen Quang
The United States of America as represented by the Secretary of
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