Compositions and methods for diagnosing and treating severe...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S004000, C536S023720, C536S024320, C536S024330

Reexamination Certificate

active

07371525

ABSTRACT:
The present invention relates to the fields of immunochemistry and pharmacology. Methods and compositions are described for the diagnosis and treatment of SARS CoV infection. More specifically, the application discloses nucleic acids and peptides of the spike glycoprotein of SARS CoV that provide prognostic and therapeutic compositions in treatment of individuals contracting, or in danger of contracting SARS CoV. The peptides of the invention are also useful in producing antibodies against the SARS CoV glycoprotein.

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U.S. Appl. No. 10/948,915, filed Sep. 23, 2004, Lo et al.
U.S. Appl. No. 10/954,815, filed Sep. 29, 2004, Leung et al.
Marra, Marco A. et al.; “The Genome Sequence of the SARS-Associated Coronavirus”; 2003,Science, vol. 300, pp. 1399-1404.
Rota, Paul A. et al.; “Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome”; 2003,Science, vol. 300, pp. 1394-1399.
Ruan, Yijun et al.; “Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection”; 2003,The Lancet, vol. 361, pp. 1779-1785.
Tsui, Stephen, K.W. et al.; “Coronavirus Genomic-Sequence Variations and the Epidemiology of the Severe Acute Respiratory Syndrome”; Jul. 10, 2003,N. Engl. J. Med. 349;2, pp. 187-188.
Chim, S.S.C. et al.; “Genomic characterization of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong”; Nov. 29, 2003,The Lancetvol. 362, pp. 1807-1808.

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