Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Reexamination Certificate
2005-10-17
2009-08-11
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
Reexamination Certificate
active
07572601
ABSTRACT:
The present invention relates to the field of reproduction (e.g., human reproduction). In particular, the present invention provides markers (e.g., pentraxin 3 and Annexin A6), and methods of using the same to determine oocyte development potential. The present invention also provides compositions and methods for modifying oocyte development potential and assays (e.g., using markers of the present invention) for detecting gene expression associated with oocyte development potential. Such compositions and methods find use in diagnostic, research and therapeutic applications.
REFERENCES:
patent: 7041648 (2006-05-01), Mantovani
Zhang et al, “Pentraxin-3 gene expression in cumulus cells may be a molecular marker for egg quality,” (Fertility and Sterility), vol. 80, Supp. 3, Sep. 2003, p. 81, available online Oct. 1, 2003.
Hsu and Hsueh, “Tissue-Specific BcI-2 Protein Partners in Apoptosis: an Ovarian Paradigm,” Physiol Rev 80:593-614 (2000).
Lee et al., “Cumulus Cells Apoptosis as an Indicator to Predict the Quality of Oocytes and the Outcome of IVF-ET,” J Assist Reprod Genet, (2001) 18:490-8.
Host et al., “Apoptosis in human cumulus cells in relation to zona pellucida thickness variation, maturation stage, and cleavage of the corresponding oocyte after intracytoplasmic sperm injection,” Fertil Steril, (2002) 77:511-5.
El-Hefnawy and Zeleznik, “Synergism Between FSH and Activin in the Regulation of Proliferating Cell Nuclear Antigen (PCNA) and Cyclin D2 Expression in Rat Granulosa Cells,” Endocrinlogy 142:4357-62, (2001).
Pangas et al., “Localization of the Activin Signal Transduction Components in Normal Human Ovarian Follicles: Implications for Autocrine and Paracrine Signaling in the Ovary,” J Clin Endocr Metabol 87:2644-57, (2002).
Chun et al., “Interleukin-1B Suppresses Apoptosis in Rat Ovarian Follicles by Increasing Nitric Oxide Production,” Endocrinology. 136:3120-7, (1995).
Chen and Ioannou, “Ribosomal Proteins in Cell Proliferation & Apoptosis,” Intl Rev Immun (1999) 18:429-48.
Gewurz et al., “Structure and function of the pentraxins,” Current Opinion in Immunology. 7:54-64 (1995).
Varani et al., “Knockout of Pentraxin 3, a Downstream Target of Growth Differentiation Factor-9, Causes Female Subfertility,” Molecular Endocrinology. 16:1154-67 (2002).
Breviario et al., “Interleukin-l-Inducible Genes in Endothelial Cells,” J. Biol. Chem., (1992) 267:22190-22197.
Confino Edmond
Kazer Ralph R.
Zhang Xingqi
Casimir Jones S.C.
Gitomer Ralph
Northwestern University
Wood Amanda P
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