Compositions and methods for detection of sirolimus

Details Compositions and methods for detection of sirolimus Compositions and methods for detection of sirolimus

2007-03-13

2007-03-13

Le, Long V. (Department: 1641)

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

C436S056000, C436S815000, C435S007100, C435S007930, C530S389800, C530S403000, C530S405000, C530S807000, C540S456000

Reexamination Certificate

active

11116928

ABSTRACT:
Compounds are disclosed comprising a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, linked to a sirolimus compound at position 26 or at position 32. Such sirolimus compounds comprising an immunogenic carrier can be employed to raise both polyclonal and monoclonal antibodies to the sirolimus compound. Polyclonal antibodies are also disclosed, which are raised against a compound wherein a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, is linked to a sirolimus compound at position 32. The above antibodies and sirolimus compounds comprising a label can be used in assays for the detection of sirolimus compounds.

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