Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Amino acid or sequencing procedure
Patent
1992-04-29
1995-06-27
Robinson, Douglas W.
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
Amino acid or sequencing procedure
436 86, G01N 3300
Patent
active
054279542
ABSTRACT:
The subject invention concerns novel materials and methods for the detection, treatment, and prevention of human osteoarthritis. Specifically, the cleavage site where aggrecanase cleaves aggrecan has been identified. Identification of this site, as well as the nature of the enzyme, facilitates specific treatments which block or diminish the activity of the enzyme. A further aspect of the invention concerns methods for detecting evidence of osteoarthritis.
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Flannery Carl R.
Lohmander L. Stefan
Neame Peter J.
Sandy John D.
Robinson Douglas W.
Shriner's Hospitals for Crippled Children
Varma Anita
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