Compositions and methods for detection and treatment of...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07655398

ABSTRACT:
The present invention relates to methods for treatment and diagnosis of disorders associated with abnormally proliferating cells. In one aspect the invention relates to methods, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides.

REFERENCES:
patent: 2003/0108871 (2003-06-01), Kaser
patent: 2003/0235820 (2003-12-01), Mack et al.
patent: WO 97/05253 (1997-02-01), None
patent: WO 98/53319 (1998-11-01), None
patent: WO 00/52204 (2000-09-01), None
Coy et al (Genomics, 1996, 32:309-316).
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
sequence comparison.
Langbein et al (British Journal of Cancer, 2006, 1-8).
Langbein, et al; “Expression of Transketolase TKTLI Predicts Colon and Urothelial Cancer Patient Survival: Warburg Effect Reinterpreted”; British Journal of Cancer, 2006; 94(4); pp. 578-585.
Coy, J, et al; “Molecular Cloning of Tissue-Specific Transcripts of a Transketolase-Related Gene: Implications for the Evalustion of New Vertebrate Genes”; Genomics; vol. 32; No. 3 ; pp. 309-316; 1996.
Cascante, M., et al; “Role of Thiamin (Vitamin B-1) and Transketolase in Tumor Cell Proliferation”; Nutrition and Cancer; vol. 36, No. 2; 2000; pp. 150-154.
Spentzos, et al; “Transketolase Gene Expression May Be a marker of Sensitivity to Platinum/Paclitaxel Chemotherapy in Ovarian Cancer”; Procedings of the American Association for Cancer Research Annual Meeting; vol. 43; Mar. 2002; pp. 1105-1106.
Lynch, H, et al; “Hereditary Cancer: Family History, Diagnosis, Molecular Genetics, Ecogenetics, and Management Strategies”; Biochemie; vol. 84; No. 1; Jan. 2002; pp. 3-17.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions and methods for detection and treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for detection and treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for detection and treatment of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4178715

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.