Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-01-04
2005-01-04
Brumback, Brenda (Department: 1654)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S040500
Reexamination Certificate
active
06838248
ABSTRACT:
Presented is a method to detect precancerous states in mammalian cell and tissue samples comprising incubating a sample with solubilized 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine (TCPP), measuring TCPP fluorescence in the sample, and categorizing the sample as non-cancerous, precancerous or cancerous based on TCPP fluorescence, as correlated with the respective states of the cells. In conjunction with the method a detection, a novel and more efficient method of solubilizing TCPP is presented, as well as a composition comprising TCPP solubilized by this method.
REFERENCES:
patent: 4485086 (1984-11-01), Wong
patent: 4783529 (1988-11-01), Lavallee et al.
patent: 4857300 (1989-08-01), Maksem
patent: 4930516 (1990-06-01), Alfano et al.
patent: 5004811 (1991-04-01), Bommer et al.
patent: 5162231 (1992-11-01), Cole et al.
patent: 5391547 (1995-02-01), Cole et al.
patent: 6190877 (2001-02-01), Adair
patent: 6316215 (2001-11-01), Adair et al.
Copy of the PCT International Search Report dated May 1, 2003 (PCT/US01/43239).
M.W. Berns et al. “In Vitro Cellular Effects of Hematoporphyrin Derivative.” Cancer Research, vol. 42, No. 6 cnrea 8, Jun. 1982, pp. 2325-2328.
Cole, D.A. et al. “Copper-67 Labeled Porphyrin Localization In Inflamed Tissue.” Copper Bioavailability and Metabolism, Mar. 29, 1990, pp. 259-272.
Cole, D.A. et al. “The Biological Characteristics of a Water Soluble Porphyrin in Rat Lymph Nodes.” Nucl. Med. Biol., vol. 17, No. 5, 1990, pp. 457-464.
D. A. Cortese et al., “Hematoporphyrin Derivative in the Detection and Localization of Radiographically Occult Lung Cancer,” Am. Rev. Respir. Dis. vol. 126, No. 1, 1087-1088 (1982).
Biological Abstracts vol. 82, No. 8, 1986, Philadelphia, PA, US; abstract No. 75075, M. Dellinger et al., “Cellular uptake of hydroxyethylvinyldeuteroporphyrin and photoinactivation of cultivated human leukemia(REH6)cells,” Abstract p. AB-679 of Photochem. Photobiol., vol. 43, No. 6 , 1986, pp. 639-648.
Firnau, G. et al. “Cu Labeling of Hematoporphyrin Derivative for Non-Invasive In-Vivo Measurements of Tumor Uptake.” Porphyrin Localization and Treatment of Tumors, Alan R. Liss, Inc., ed, 1984, pp. 629-636.
Hambright, P. et al. “The Distribution of Various Water Soluble Radioactive Metalloporphyrins in Tumor Bearing Mice.” Bioinorganic Chemistry, vol. 5, 1975, pp. 87-92.
Kato, H. et al. “Early Detection of Lung Cancer by Means of Hematoporphyrin Derivative Fluorescence and Laser Photoradiation.” Clinics in Chest Medicine, vol. 6, No. 2, Jun. 1985, pp. 237-253.
J. A. Mercer-Smith et al., “The Development of Copper-67-Labeled Porphyrin-Antibody Conjugates,” Targeted Diagnosis and Therapy, vol. 1, Antibody-Mediated Delivery Systems; J. D. Rodwell, Ed. (Marcel-Dekker), New York, 1988 pp. 317-352.
Biological Abstracts vol. 68, No. 10, 1979, Philadelphia, PA, US; abstract No. 62117, J. Moan et al., “The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin, ” Abstract p. 6230, BR. J. Cancer, vol. 39, No. 4, 1979, pp. 398-407.
Biological Abstracts vol. 85, No. 5, 1988, Philadelphia, PA, US; abstract No. 49732, J. Moan et al., “Photosensitizing efficiencies, tumor and cellular uptake of different photosensitizing drugs relevant for photodynamic therapy of cancer.” Abstract p. AB-723 of Photochem. Photobiol., vol. 46, No. 5, 1987, pp. 713-722.
Biological Abstracts vol. 86, No. 7, 1988, Philadelphia, PA, US; abstract No. 72079, J. Moan et al., “A change in the quantum yield of photoinactivation of cells observed during photodynamic treatment.” Abstract p. AB-772 of Lasers Med. Sci., vol. 3, No. 2, 1988, pp. 93-98.
Musser, D.A. et al. “The Binding of Tumor Localizing Porphyrins to a Fibrin Matrix and Their Effects Following Photoirradiation.” Res. Comm. In Chem. Path. and Pharm., vol. 28, No. 3, Jun. 1980, pp. 505-525.
Patel, K.B. “Fluorescing Cells In Sputum After Parenteral HPD.” Porphyrin Localization and Treatment of Tumors, Alan R. Liss, Inc., ed, 1984, pp. 521-530.
Roberts, J.C. “Preparation and characterization of copper-67 porphyrin-antibody conjugates.” Journal of Immun. Methods, vol. 105, 1987, pp. 153-164.
Shulok, J.R. et al. “Subcellular Localization of Hematoporphyrin Derivative in Bladder Tumor Cells in Culture.” Photochem. And Photobiol., vol. 51, No. 4, 1990, pp. 451-457.
BioModa, Inc.
Brumback Brenda
Winston Randall
Woodcock & Washburn LLP
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