Chemistry: analytical and immunological testing – Phosphorus containing – Organic
Reexamination Certificate
2011-05-31
2011-05-31
Griffin, Walter D (Department: 1774)
Chemistry: analytical and immunological testing
Phosphorus containing
Organic
C436S103000, C564S265000, C564S253000, C564S248000, C564S001000, C588S303000, C588S001000, 59, 59, 59
Reexamination Certificate
active
07951607
ABSTRACT:
The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a moderately good leaving group at the phosphorus. Selectivity in the present invention is provided by a sensor composition having an alpha (α) effect nucleophile group that undergoes specific nucleophilic substitution and rearrangement reactions with phosphorus based nerve agents having a tetrahederal phosphorous bound to oxygen. The present invention includes embodiments employing a sensor composition further comprising a reporter group covalently linked to the alpha effect nucleophile group allowing rapid optical readout of nerve agent detection events, including direct visual readout and optical readout via spectroscopic analysis.
REFERENCES:
patent: 2926072 (1960-02-01), Kramer et al.
patent: 5327211 (1994-07-01), Carron et al.
patent: 5576216 (1996-11-01), Patchornik
patent: 7674627 (2010-03-01), Corcoran et al.
patent: WO 98/59234 (1998-12-01), None
Geier et al., Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant, Contact Dermitis, 2003, 48, 99-107.
Angel et al. (1990) “Development of a Drug Assay Using Surface-Enhanced Raman Spectroscopy,”SPIE1201:469-473.
Akiyama et al. (1981) “Ethynologs of Triphenylmethane Dyes. Syntheses and Properties of Acetylenic Analogs of Malachite Green, Crystal Violet, and Their Related Compounds,”Chem. Lett.:311-314.
Akiyama et al. (1987) “Triphenylmethane Dye Ethynologues with Absorption Bands in the Near I.R.,”J. Chem. Soc. Chem. Commun.:710-711.
Cabalin et al. (1993) “Surface-Enhanced Raman Spectrometry for Detection in Liquid Chromatography Using a Windowless Flow Cell,”Talanta, 40(11):1741-1747.
Carey et al. (1978) “Resonance Raman Labels: A Submolecular Probe for Interactions in Biochemical and Biological Systems,”Accounts of Chemical Research11:122-128.
Hackley et al. (1955) “Acceleration of the Hydrolysis of Organic Fluorophosphates and Fluorophosphanates with Hydroxamic Acids,”J. Am. Chem. Soc.77:3651-3653.
Heyns et al. (1994) “SERS Study of the Interaction of Alkali Metal Ions with Thiol-Derivatized Dibenzo-18-Crown-6,”Anal. Chem.66(9):1572-1574.
Hurd et al. (1954) “A Novel Rearrangement of Hydroxamic Acids Using Sulfonyl Chlorides,”J. Am. Chem. Soc.76:2791-2792.
Hurd et al. (1939) “Hydroxylamine,” In;Inorganic Synthesis,vol. 1, pp. 87-89.
Jones et al. (1921) “Rearrangements of Some New Hydroxamic Acids Related to Heterocyclic Acids and to Diphenyl- and Triphenyl-Acetic Acids,”J. Am. Chem. Soc.43:2422-2448.
Lacey, R.J. (1997) “Some Advances in the Use of Raman Spectroscopy in Security Screening Applications,”IEE Conference Publication437:10-12.
Mullen et al. (Jun. 1992) “Trace Detection of Ionic Species with Surface Enhanced Raman Spectroscopy,”Spectroscopy7(5):24-31.
Storey et al. (1995) “Applications of Surface-Enhanced Raman Scattering (SERS) to Chemical Detection,”Spectroscopy10(3):20-25.
Torres et al. (Jul. 1987) “Trace Determination of Nitrogen-Containing Drugs by Surface Enhanced Raman Scattering Spectroscopy on Silver Colloids,”Anal. Chem.59(13):1626-1632.
Wachter et al. (1995) “Hybrid Substrates for Real-Time SERS-Based Chemical Sensors,”Appl. Spectrosc.49(2):193-199.
Weiberth et al. (1987) “Copper(I)-Activated Addition of Grignard Reagents to Nitriles. Synthesis of Ketimines, Ketones, and Amines,”J. Org. Chem.52:3901-3904.
Yale et al. (1943) “The Hydroxamic Acids,”Chem. Rev.33:209-256.
Zhang et al. (2003) Fluorescent Detection of Chemical Warfare Agents: Functional Group Specific Ratiometric Chemosensors,J. Am. Chem. Soc.125:3420-3421.
Inorganic Syntheses, McGraw-Hill Book Company, Inc., vol. 1, Chapter 5, section 30, p. 87 (1939).
Corcoran Robert C.
Strickland Aaron D.
Greenlee Sullivan P.C.
Griffin Walter D
Mui Christine T
University of Wyoming
LandOfFree
Compositions and methods for detecting nerve agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for detecting nerve agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for detecting nerve agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2657095