Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-06-10
2008-06-10
Chernyshev, Olga N. (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S004000, C436S501000, C436S503000, C436S504000, C536S024300
Reexamination Certificate
active
07384748
ABSTRACT:
The present invention relates to the NTE proteins and nucleic acids encoding the NTE proteins. The present invention further provides assays for the detection of NTE polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NTE proteins.
REFERENCES:
patent: 2005/0003390 (2005-01-01), Axenovich et al.
Winrow, C. J., et al., “Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity,” (2003) Nature Genetics 33: 477-485.
Bargal, R., et al., “Identification of the gene causing mucolipidosis type IV,” (2000) Nature Genetics 26: 118-123.
Lush, M. J., et al., “Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man,” (1998) Biochem. J. 332: 1-4.
Moser, M., et al., “Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice,” (2004) Molec. Cell. Biol. 24: 1667-1679.
O'Callaghan, J P. “Neurotoxic esterase: not so toxic?,” (2003) Nature Genetics 33: 437-438.
Fink John K.
Rainer Shirley
Casimir Jones S.C.
Chernyshev Olga N.
The Regents of the University of Michigan
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