Compositions and methods for dendritic cell-based immunotherapy

Details Compositions and methods for dendritic cell-based immunotherapy Compositions and methods for dendritic cell-based immunotherapy

2005-06-03

2010-02-09

Rawlings, Stephen L (Department: 1643)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Rodent cell, per se

C435S372000, C530S300000, C530S350000

Reexamination Certificate

active

07659117

ABSTRACT:
Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and methods for immunotherapy using the compositions.

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