Compositions and methods for delivery of photosensitive drugs

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

Reexamination Certificate

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Reexamination Certificate

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07455858

ABSTRACT:
The invention provides nanoparticles containing photosensitizers and their use in the field of photodynamic therapy (PDT). The invention also provides methods for the preparation of such nanoparticles as well as for their sterilization.

REFERENCES:
patent: 4968350 (1990-11-01), Bindschaedler et al.
patent: 5707608 (1998-01-01), Liu
patent: 5798349 (1998-08-01), Levy et al.
patent: 2002/0127224 (2002-09-01), Chen
patent: 0 276 121 (1988-07-01), None
patent: WO 97 10811 (1997-03-01), None
Scoles, P.D. et al., The preparation of sub-200nm poly(lactide-co-clycolide) microspheres for site-specific drug delivery, 1993, J. of Controlled Release, 25, 145-153.
Allemann et al., Eur. J. Pharm. Biopharm. 39(5):173-191 (1993).
Allemann, E. et al., “In Vitro Extended-Release Properties of Drug Loaded Poly(D,L-Lactic Acid) Nanoparticles Produced by a Salting-out Procedure” Pharm. Res. 10:1732-1737 (1993b).
Allemann, E. et al., “Distribution, Kinetics and Elimination of Radioactivity after Intravenous and Intramuscular Injection of 14C-Savoxepine Loaded Poly(D,L-Lactic Acid) Nanospheres to Rats” J. Controlled Release 29:97-104 (1994).
Allemann, E. et al., “Biodegradable Nanoparticles of Poly(Lactic Acid) and Poly(Lactic-Co-Glycolic Acid) for Parenteral Administration”In Pharmaceutical Dosage Forms: Disperse Systems(Lieberman, H. et al., Eds.) Marcel Dekker, Inc. New York 3: 163-193 (1998).
Athanasiou, K. and Niederauer, G., “Sterilization, Toxicity, Biocompatibility and Clinical Applications of Polylactic Acid/Polyglycolic Acid Copolymers” Biomaterials 17:93-102 (1996).
Beck, L. et al., Obstet. Gynecol. 147:815-821 (1983).
Bindschaedler et la., J. Pharm. Sci. 77(8):696-698 (1998).
De Chasteigner, S. et al., “Gastro-Intestinal Tolerance Study of a Freeze-Dried Oral Dosage Form of Indomethacin-Loaded Nanocapsules” S. T. P. Pharma Sciences 5:242-246 (1995).
De Chasteigner, S. et al., “Freeze-Drying of Itraconazole-Loaded Nanosphere Suspensions: A Feasibility Study” Drug Dev. Res. 116-124 (1996).
DeLuca, P. and Boylan, J., “Formulation of Small Volume Parenterals”In Pharmaceutical Dosage Forms: Parenteral MedicationsAvis, K., et al., (eds.) M. Dekker, Inc. New York 1:139-201 (1984).
Douglas, S. et al., “Nanoparticles in Drug Delivery” CRC Crit. Rev. in Ther. Drug Carrier Syst. 3:233-260 (1987).
El-Samaligy, M. and Rohdewald, P., “Triamcinolone Diacetate Nanoparticles, Sustained Release Drug Delivery System Suitable for Parental Administration” Pharm. Acta. Helv. 57(7):201-4 (1982).
Harmia, T. et al., “Nanoparticles as Drug Carriers in Ophthalmology” Pharm. Acta. Helv. 62:322 (1987).
Hausberger, A. et al., “Gamma Irradiation Effects on Molecular Weight and In Vitro Degradation of Poly(D,L-Lactide-Co-Glycolide) Microspheres” Pharm. Res. 12:851-856 (1995).
Jalil, R., “Biodegradable Poly(Lactic Acid) and Poly(Lactide-Co-Glycolide) Polymers in Sustained Drug Delivery” Drug Dev. Ind. Pharm. 16:2353 (1990).
Kattan, J. et al., “Phase I Clinical Trial and Pharmacokinetic Evaluation of Doxorubicin Carried by Polyisohexylcyanoacrylate Nanoparticles” Invest. New Drugs 10:191-199 (1992).
Kawashima, Y. et al., “Properties of a Peptide Containing DL-Lactide/Glycolide Copolymer Nanospheres Prepared by Novel Emulsion Solvent Diffusion Methods” Eur. J. Pharm. Biopharm. 45:41-48 (1998).
Konan et al., “Preparation and Characterization of Sterile Sub-200 nm Meso-Tetra (4-hydroxylphenyl) Porphyrin-Loaded Nanoparticles for Photodynamic Therapy” Eur. J. Pharma. and Biopharma. 55(1):115-124 (2003).
Konan et al., “Enhanced Photodynamic Activity of Meso-Tetra (4-Hydroxyphenyl) Porphyrin by Incorporation into Sub-200 nm Nanoparticles” Eur. J. Pharma. Sciences: Official J. of Eur. Fed. For Pharma. Sciences 18(3-4):241-249 (2003).
Konan et al., “Encapsulation of p-THPP into Nanoparticles: Cellular Uptake, Subcellular Localization and Effect of Serum on Photodynamic Activity” Photochem. and Photobio. 77(6):638-644 (2003).
Mohr, D. et al., “Gamma Irradiation for Terminal Sterilization of 17-Estradiol Loaded Poly-(D,L-Lactide-Co-Glycolide) Microparticles” J. Control. Rel. 61:203-217 (1999).
Montanari, L. et al., “Gamma Irradiation Effects on Poly(D,L-Lactide-Co-Glycolide) Microspheres” J. Control. Rel. 56:219-229 (1998).
Rodrigues Jr., J. et al., “Primaquine-Loaded Poly(Lactide) Nanoparticles: Physicochemical Study and Acute Tolerance in Mice” Int. J. Pharm. 126:253-260 (1995).
Rolland, “Clinical Pharmacokinetics of Doxorubicin in Hepatoma Patients after a Single Intravenous Injection of Free or Nanoparticles Bound Anthracycline” Int. J. Pharm. 54:113-121 (1989).
Scholes, P. et al., “The Preparation of Sub-200 nm Poly(Lactide-Co-Glycolide) Microspheres for Site-Specific Drug Delivery” J. Control. Rel. 25:145-153 (1993).
Smith, A. and Hunneyball, I. et al., “Evaluation of Poly(Lactic Acid) as a Biodegradable Drug Delivery System for Parenteral Administration” Int. J. Pharm. 30:215-220 (1986).
Tasset, C. et al., “Polyisobutylcyanoacrylate Nanoparticles as Sustained Release System for Calcitonin” J. Control. Rel. 33:23 (1995).
Vert, M., “Structure et Comportement des Polymeres. Exemples des Polymeres Bioresorbables” S.T.P. Pharma 3:216-222 (1987).
Vert, M. et al., “Something New in the Field of PLA/GA Bioresorbable Polymers?” J. Control. Rel. 53:92 (1998).
Volland, C. et al., “The Influence of Terminal Gamma-Sterilization on Captopril Containing Poly(D,L-Lactide-Co-Glycolide) Microspheres” J. Control. Rel. 31:293-305 (1994).
Yoo, H. et al., “Biodegradable Nanoparticles Containing Doxorubicin-PLGA Conjugate for Sustained Release” Pharm. Res. 16:1114 (1999).
Cook et al., Photochemistry and Photobiology (1995) 62(3):542-545.
Saltzman,Drug Delivery: Engineering Principles for Drug Therapy, Oxford University Press, 2001, pp. 334-345 (Appendix A).

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