Compositions and methods for decreasing sebum production

Details Compositions and methods for decreasing sebum production Compositions and methods for decreasing sebum production

1994-08-31

2000-10-17

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Dermatitis

Acne

514864, A61K 748, A61K 3117

Patent

active

061333263

ABSTRACT:
A method of treating diseases caused by sebaceous gland disorders, in humans and animals, which comprises administering to said humans and animals a composition comprising a sebaceous gland secretion inhibiting amount of an active compound comprising an acyl coA cholesterol acyl transferase (ACAT) inhibitor or prodrug therefor.
A composition for use in treating diseases caused by sebaceous gland disorders such as acne in humans and animals which comprises a sebaceous gland secretion inhibiting amount of an acyl coA cholesterol acyl tanferase (ACAT) inhibitor or prodrug therefor and, optionally, a pharmaceutically acceptable carrier.

REFERENCES:
patent: 4302456 (1981-11-01), Voorhees et al.
patent: 4514385 (1985-04-01), Damani et al.
patent: 4716175 (1987-12-01), Hoefle et al.
patent: 4994465 (1991-02-01), Trivedi
patent: 5204093 (1993-04-01), Victor
Reindel et al., 1994, Sep.-Oct. Toxicologic Pathology 22(5):510-518, "Toxicologic effects of a novel acyl-CoA:cholesterol acyltransferase inhibitor in cynomolgus monkeys", including corresponding abstract from PubMed (NCBI).

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