Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-09-12
1999-11-16
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514221, 514814, 514825, 514826, 514863, 514866, 514894, 514903, A61K 3133, A61K 3155
Patent
active
059858630
ABSTRACT:
The present invention relates to methods and pharmaceutical compositions for decreasing the production of interferon-gamma inducing factor (IGIF). The invention also relates to methods and pharmaceutical compositions for decreasing the production of interferon-gamma (IFN-.gamma.). The compositions comprise a therapeutically effective amount of a compound which inhibits interleukin-1.beta. converting enzyme (ICE) and a pharmaceutically acceptable carrier. The methods comprise the step of administering the above compositions to a subject. The present invention also relates to methods for treating or reducing the advancement, severity or effects of an IGIF- or IFN-.gamma.-mediated inflammatory, infectious or autoimmune condition.
REFERENCES:
patent: 5656627 (1997-08-01), Bemis et al.
J. Fernando Bazan, "A Newly Defined Interleukin-1?", Nature, 379, p. 591 (Feb., 1996).
Gu Yong
Livingston David J.
Su Michael
Dixon Lisa A.
Haley, Jr. James F.
Jordan Kimberly
Vertex Pharmaceuticals Inc.
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