Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-10-16
1999-10-26
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514513, 514851, A61K 3135, A61K 3121
Patent
active
059729953
ABSTRACT:
Compositions and methods for therapy of cystic fibrosis and other conditions are provided. The compositions comprise one or more flavones and/or isoflavones capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involve the administration (e.g., orally or via inhalation) of such compositions to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of chloride transport.
REFERENCES:
patent: 5639661 (1997-06-01), Welsh et al.
patent: 5650433 (1997-07-01), Watanabe et al.
patent: 5733926 (1998-03-01), Gorbach
patent: 5756538 (1998-05-01), Cassels et al.
Brown et al., "Chemical chaperones correct the mutant phenotype of the .DELTA.F508 cystic fibrosis transmembrane conductance regulatory protein," Cell Stress & Chaperones 1(2): 117-125, 1996.
Hwang et al., "Genistein potentiates wild-type and .DELTA.F508-CFTR channel activity," American Journal of Physiology273(3, part 1): C988-C-998, 1997.
Scott and Cooperstein, "Ascorbic acid stimulates chloride transport in the amphilbian cornea," Investigative Ophtalmology 14(10): 763-766, 1975.
Smith, "Treatment of cystic fibrosis based on understanding CFTR," J. Inher. Metab. Dis 18:508-516, 1995.
Rubenstein et al., "In Vitro Pharmacologic Restoration of CFTR-mediated Chloride Transport with Sodium 4-Phenylbutyrate in Cystic Fibrosis Epithelial Cells," J. Clin. Invest. 100(10): 2457-2465, 1997.
Sheppard et al., "Mutations in CFTR associated with mild-disease-form CI channels with altered pore properties," Nature 362: 160-164, 1993.
Anderson, et al., "Generation of cAMP-Activated Chloride Currents by Expression of CFTR," Science 251:679-682, 1991.
Knowles et al., "In Vivo Nasal Potential Difference: Techniques and Protocols for Assessing Efficacy of Gene Transfer in Cystic Fibrosis," Human Gene Therapy 6: 445-455, 1995.
Riordan et al., "Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA," Science 245: 1066-1073, 1989.
Illek et al., "cAMP-independent activation of CFTR C1 channels by the tyrosine kinase inhibitor genistein," Cell Physiol. 37: C886-C893, 1995.
Fischer Horst Bernhard
Illek Beate
Children's Hospital Medical Center of Northern California
Weddington Kevin E.
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