Compositions and methods for controlling genetically engineered

Details Compositions and methods for controlling genetically engineered Compositions and methods for controlling genetically engineered

1998-02-06

2000-09-26

Yucel, Remy

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

2352523, C12N 120

Patent

active

061241296

ABSTRACT:
Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin. The general requirement for biotin through the living world makes streptavidin-based conditional lethal designs applicable to a broad range of containment strategies.

REFERENCES:
patent: 5679533 (1997-10-01), Szafranski et al.
patent: 5681745 (1997-10-01), Szafranski et al.

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