Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Reexamination Certificate
2005-06-14
2005-06-14
Kerr, Kathleen (Department: 1652)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
C435S069100
Reexamination Certificate
active
06905877
ABSTRACT:
Methods and compositions for altering amino acid composition of a protein of interest are provided, particularly proteins whose three-dimensional structure is unknown. The method comprises creating interacting molecules to the native protein and selecting for engineered proteins which retain the native conformation by antibody binding. In this manner, the levels of essential amino acids in a protein can be increased yet the biological activity of the protein maintained. Also provided is an exemplary plant protein—Glycine maxvegetative storage protein (VSP)—in which methionine levels have been increased.
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Rao A. Gururaj
Sleister Heidi Major
Alston & Bird LLP
Kerr Kathleen
Pioneer Hi-Bred International , Inc.
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