Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-03-04
2008-03-04
Siew, Jeffrey (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023700, C424S184100, C424S237100, C424S243100
Reexamination Certificate
active
11063308
ABSTRACT:
A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants inStaphylococcus aureusis provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A preferred embodiment of the present invention provides structural information relating to the gene product and enables the identification and formulation of lead compounds and reducements for treating and preventing infections byS. aureusand related bacteria.
REFERENCES:
Heinrichs et al (Journal of Bacteriology, Jan. 1996, p. 418-423).
Bayer et al (Journal of Bacteriology, Aug. 1996, p. 4563-4570).
Manna et al (Infection and Immunity, Aug. 1998, p. 3828-3836).
Manna et al (Infection and Immunity, Feb. 2001, p. 885-896).
(NCBI Database, Genebank, Accession No. AF207701 date created Dec. 1, 2000).
Bayer et al., “The Molecular Architecture of thesarLocus inStaphylococcus aureus”, Journal of Bacteriology 1996 178 (15):4563-4570.
Cheung et al., “Regulation of exoprotein expression inStaphylococcus aureusby a locus (sar) distinct fromagr”, Proc. Natl. Acad. Sci. USA 1992 89:6462-6466.
Cheung et al., “Cloning and Sequencing ofsarAofStaphylococcus aureus, a Gene Required for the Expression ofagr”, Journal of Bacteriology 1994 176(13):4168-4172.
Cheung et al., “sarGenetic Determinants Necessary for Transcription of RNAII and RNAIII in theagrLocus ofStaphylococcus aureus”, Journal of Bacteriology 1997 179(12):3963-3971.
Manna et al., “Transcriptional Analysis of Different Promoters in thesarLocus inStaphylococcus aureus”, Journal of Bacteriology 1998 180(15):3828-3836.
Manna et al., “Characterization ofsarR, a Modulator ofsarExpression inStaphylococcus aureus”, Infection and Immunity 2001 69(2):885-896.
Tegmark et al., “Identification and characterization of SarH1, a new global regulator of virulence gene expression inStaphylococcus aureus”, Molecular Microbiology 2000 37(2):398-409.
Cheung Ambrose L.
Manna Adhar
Ford Vanessa L.
Licata & Tyrrell P.C.
Siew Jeffrey
Trustees of Dartmouth College
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