Compositions and methods for affecting virulence...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023100

Reexamination Certificate

active

10043539

ABSTRACT:
A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants inStaphylococcus aureusis provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A preferred embodiment of the present invention provides structural information relating to the gene product and enables the identification and formulation of lead compounds and reducements for treating and preventing infections byS. aureusand related bacteria.

REFERENCES:
patent: 5587288 (1996-12-01), Cheung et al.
patent: 5976792 (1999-11-01), Cheung et al.
patent: 6020121 (2000-02-01), Bao et al.
patent: 6380370 (2002-04-01), Doucette-Stamm et al.
patent: 6656735 (2003-12-01), Wurst et al.
patent: 6699662 (2004-03-01), Hurlburt et al.
patent: 6927059 (2005-08-01), Cheung
patent: 2003/0124597 (2003-07-01), Cheung
patent: 2003/0148492 (2003-08-01), Alekshun et al.
patent: 2003/0171563 (2003-09-01), McNamara
patent: 2004/0147734 (2004-07-01), Doucette-Stamm et al.
patent: WO 01/03686 (2001-01-01), None
patent: WO 02/068610 (2002-09-01), None
Tegmark, K et al, Molecular Microbiology, 2000, vol. 37(2), pp. 398-409.
Chan, PF et al, J. Bacteriology, Dec. 1998, vol. 180 (23), pp. 6232-6241.
Manna, AC et al, J. Bacteriology, Aug. 1998, vol. 180(15), pp. 3828-3836.
Manna, A et al, Infection and Immunity, vol. 69(2), pp. 885-896, Feb. 2001.
Chien, Yueh-tyng et al, J. of Biological Chemistry, vol. 273(5) Jan. 30, 1998m pp. 2645-2652.
Chien, Yueh-tyng e tal, Molecular Microbiology, 1998, vol. 30(5), pp. 991-1001.
Cheung, AL et al, Infeciton and Immunity, vol. 66(12), pp. 5988-5993, Dec. 1998.
Fluckiger, U et al, Infeciton and Immunity, Jun. 1998, vol. 66(6), pp. 2871-2878.
Topham et al., “Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables”, Protein Engineering 1997 10(1):7-21.
Tretiakova et al., “Rational design of cytotoxic T-cell inhibitors”, Nature Biotechnology 2000 18:984-988.
Bayer et al., “The Molecular Architecture of the sar Locus inStaphylococcus aureus”, Journal of Bacteriology 1996 178(15):4563-4570.
Cheung et al., “Regulation of exoprotein expression inStaphylococcus aureusby a locus (sar) distinct from agr”, Proc. Natl. Acad. Sci. USA 1992 89:6462-6466.
Cheung et al., “Cloning and Sequencing of sarA ofStaphylococcus aureus, a Gene Required for the Expression of agr”, Journal of Bacteriology 1994 176(13):4168-4172.
Cheung et al., “sar Genetic Determinants Necessary for Transcription of RNAII and RNAIII in the agr Locus ofStaphylococcus aureus”, Journal of Bacteriology 1997 179(12):3963-3971.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions and methods for affecting virulence... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for affecting virulence..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for affecting virulence... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3863272

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.