Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Patent
1990-04-06
1991-12-03
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
5142265, 514165, 514474, 514784, 514785, 514777, 514946, A61K 3162, A61K 3160, A61K 3134, A61K 4700
Patent
active
050700855
ABSTRACT:
A composition useful for administering therapeutically active compounds to improve the body absorption and/or retention thereof comprising a composition includes a therapeutically active compound having a molecular weight below about 5,000, having an acidic functional group and a pKa of .ltoreq.6 at pH 7.4 normally eliminated unmetabolized from the body via the renal tubular secretion pathway for organic anions, for example, Vitamin C, and at least one compound selected from the class consisting of L-threonic, L-xylonic and L-lyxonic acids, and the edible salts, aldono-lactones and aldono-lactides thereof.
A method for establishing and maintaining body levels of a therapeutically active compound includes the step of administering a therapeutically effective dose of this composition.
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patent: 4968716 (1990-11-01), Markham
Lewin, S. "Vitamin C: Its Molecular Biology and Medical Potential" (1976) pp. 12-13.
Thomas et al., Chem. Toxic. vol. 21 (4) pp. 449-52 (1983).
Morrison and Boyd--Organic Chemistry, 3rd edition, copyright 1973 (N. Y. University, Allyn and Bacon Inc.) p. 1075, Table 34.1.
Henley, III. Raymond J.
Oxycal Laboratories, Inc.
Waddell Frederick E.
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