Compositions and methods for activating genes of interest

Details Compositions and methods for activating genes of interest Compositions and methods for activating genes of interest

2006-05-30

2006-05-30

McGarry, Sean (Department: 1635)

Chemistry: molecular biology and microbiology

Vector, per se

C435S069100, C536S024100, C536S024500, C536S023100, C514S04400A

Reexamination Certificate

active

07052903

ABSTRACT:
Compositions and methods for activating genes of interest are provided. The compositions comprise a masked targeted expression cassette which expresses a gene product only in the presence of a target molecule. The cassettes are useful for the treatment of disease and for preventing the proliferation of neoplastic cells.

REFERENCES:
Anderson, “Human Gene Therapy,”Nature, Apr. 30, 1998, pp. 25-30, vol. 392.
Branch, “A Good Antisense Molecule is Hard to Find,”TIBS 23, Feb. 1998, pp. 45-50, Elsevier Science Ltd.
Coleman et al., “The Use of RNA's Complementary to Specific mRNAs to Regulate the Expression of Individual Bacterial Genes,”Cell, Jun. 1984, pp. 429-435, vol. 37.
Hirashima et al., “Engineering of the m-RNA-Interfering Complementary RNA Immune System Against Viral Infection,”Proceeding of the National Academy of Sciences, USA, Oct. 1986, pp. 7726-7730, vol. 83.
Verma et al., “Gene Therapy—Promises, Problems and Prospects,”Nature, Sep. 18, 1997, pp. 239-242, vol. 389.

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