Compositions and methods employing 2-oxa- or -aza-pregnan compou

Details Compositions and methods employing 2-oxa- or -aza-pregnan compou Compositions and methods employing 2-oxa- or -aza-pregnan compou

1988-08-04

1990-04-03

Rivers, Diana G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514453, 546 78, 549276, A61K 31585, A61K 3157

Patent

active

049141066

ABSTRACT:
A compound represented by the following formula ##STR1## wherein A represents a hydrogen atom or a lower alkanoyl group, Z represents an oxygen atom or the group ##STR2## in which R represents a hydrogen atom or a lower alkyl group, and X represents a halogen atom, the compound being useful for controlling androgen-dependent diseases, particularly for preventing abortion or for contraception.

REFERENCES:
patent: 3080381 (1963-03-01), Pappo
patent: 3179658 (1965-04-01), Hirschmann et al.
patent: 3280133 (1966-10-01), Pappo et al.
patent: 3290287 (1966-12-01), Mazur et al.
patent: 4732897 (1988-03-01), Cainelli et al.
Applezweig, "Steroid Drugs", McGraw-Hill Book Co., New York (1962), pp. 340-341, 344, 614-615.
Djerassi, "Steroid Reactions, An Outline for Organic Chemists", Holden-Day, Inc., San Francisco (1963), p. 242.
Nace et al., J. Organic Chem., vol. 31, pp. 2109-2115 (1966).

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