Compositions and methods comprising 2-mercaptomethylglutaric aci

Details Compositions and methods comprising 2-mercaptomethylglutaric aci Compositions and methods comprising 2-mercaptomethylglutaric aci

1990-01-17

1991-04-23

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514492, 514494, 514499, 514500, 514501, 514502, 514505, 514517, 514518, 514574, 556 49, 556 61, 556114, 556131, 556136, 556147, 560147, 562594, A61K 3128, C07C 5502

Patent

active

050101030

ABSTRACT:
New compounds having utility for enhancing the activity of antifolates are disclosed of the formula: ##STR1## wherein X is selected from hydrogen ##STR2## and R" ; R' is selected from alkyl, alkenyl, alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heterocyclic aryl; R" is selected from ##STR3## and R'S; M is selected from OR and secondary amine; and R is selected from hydrogen, alkyl, acyloxymethyl, substituted and unsubstituted aryl, substituted and unsubstituted heterocyclic aryl, amino cation and metal cation.

REFERENCES:
patent: 3205268 (1965-09-01), Rosenwald
patent: 3271248 (1966-09-01), Renault et al.
patent: 4172207 (1979-10-01), Mack

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